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Mutations that impair a posttranscriptional step in expression of HLA-A and -B antigens.
Open accessAbstract
Mutations can interfere with posttranscriptional expression of the HLA-A and -B genes. B-lymphoblastoid cells that contain one copy of the major histocompatibility complex (MHC) were subjected to mutagenesis and immunoselection for MHC antigen-loss mutants. Some mutations partially reduced surface expression of HLA-A and eliminated HLA-B expression concurrently, although the HLA-A and -B genes were present and transcribed. Antigen expression was fully restored in hybrids of these mutants with other B-lymphoblastoid cells. Therefore, normal cell surface expression of the HLA-A and -B antigens on B lymphoblasts requires (i) execution of at least one trans-active step in the production of the antigens after transcription of the HLA-A and -B genes or (ii) association of the class I antigens with other molecules. DNA analysis of one mutant suggests the possibility that a locus required for the normal expression of the HLA-A and -B antigens is located between the MHC complement genes and the HLA-DP alpha II locus.
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Citations
Cited by
MECHANISMS OF MHC CLASS I–RESTRICTED ANTIGEN PROCESSING
Pamer, E., & Cresswell, P. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.323 · Cited by 1,008
Association of class I major histocompatibility heavy and light chains induced by viral peptides
Townsend, A., Öhlén, C., Bastin, J., Ljunggren, H.-G., Foster, L., & Kärre, K. (1989) · Nature · doi:10.1038/340443a0 · Cited by 985
Assembly of MHC class I molecules analyzed in vitro
Townsend, A., Elliott, T., Cerundolo, V., Foster, L., Barber, B., & Tse, A. (1990) · Cell · doi:10.1016/0092-8674(90)90366-m · Cited by 485
Transport Protein Genes in the Murine MHC: Possible Implications for Antigen Processing
Monaco, J. J., Cho, S., & Attaya, M. (1990) · Science · doi:10.1126/science.2270487 · Cited by 430
Spies, T., & DeMars, R. (1991) · Nature · doi:10.1038/351323a0 · Cited by 406
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Metadata
- Authors
- DeMars, R., Rudersdorf, R., Chang, C., Petersen, J., Strandtmann, J., Korn, N., Sidwell, B., & Orr, H. T.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1985-12
- Volume
- 82
- Issue
- 23
- Pages
- 8183-8187
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2074737029
- Cited by
- 181
- References
- 0
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- green
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- DeMars, R., Rudersdorf, R., Chang, C., Petersen, J., Strandtmann, J., Korn, N., Sidwell, B., & Orr, H. T. (1985). Mutations that impair a posttranscriptional step in expression of HLA-A and -B antigens. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.82.23.8183
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