The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Transport Protein Genes in the Murine MHC: Possible Implications for Antigen Processing
Abstract
T lymphocyte activation requires recognition by the T cell of peptide fragments of foreign antigen bound to a self major histocompatibility complex (MHC) molecule. Genetic evidence suggests that part of the class II region of the MHC influences the expression, in trans, of MHC class I antigens on the cell surface, by regulating the availability of peptides that bind to and stabilize the class I molecule. Two closely related genes in this region, HAM1 and HAM2 , were cloned and had sequence similarities to a superfamily of genes involved in the ATP-dependent transport of a variety of substrates across cell membranes. Thus, these MHC-linked transport protein genes may be involved in transporting antigen, or peptide fragments thereof, from the cytoplasm into a membrane-bounded compartment containing newly synthesized MHC molecules.
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Cites
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Cited by
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Metadata
- Authors
- Monaco, J. J., Cho, S., & Attaya, M.
- Venue
- Science
- Published
- 1990-12-21
- Volume
- 250
- Issue
- 4988
- Pages
- 1723-1726
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1994435196
- Cited by
- 430
- References
- 47
- FWCI
- 26.74
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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