The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Control of oxidative metabolism and oxygen delivery in human skeletal muscle: a steady-state analysis of the work/energy cost transfer function.
Open accessAbstract
The concept of transfer function for organ performance (work output vs. biochemical input) is developed for skeletal and cardiac muscle under steady-state exercise conditions. For metabolic control by the ADP concentration, the transfer function approximates a Michaelis-Menten hyperbola. Variation of the work identifies metabolic operating points on the transfer function corresponding to ADP concentrations or to a ratio of inorganic phosphate to phosphocreatine that can be determined by phosphorus nuclear magnetic resonance. This operating point is characterized by the fraction (V/Vmax) of maximal activity of oxidative metabolism in the steady state. This quantity appears to be useful in predicting the degree to which metabolic homeostasis is effective; poorly controlled metabolic states can readily be identified and are used in the diagnosis and therapy of metabolic disease in the organs of neonates and adults.
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Cites
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Regulation of oxidative phosphorylation in the mammalian cell
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Regulation of skeletal muscle mitochondrial function: genes to proteins
Lanza, I. R., & Sreekumaran Nair, K. (2010) · Acta Physiologica · doi:10.1111/j.1748-1716.2010.02124.x · Cited by 83
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Skeletal muscle fuel selection occurs at the mitochondrial level
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Metadata
- Authors
- Chance, B., Leigh, J. S., Clark, B. J., Maris, J., Kent, J., Nioka, S., & Smith, D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1985-12
- Volume
- 82
- Issue
- 24
- Pages
- 8384-8388
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2025532642
- Cited by
- 381
- References
- 1
- FWCI
- 22.71
- Type
- journal article
- Language
- en
- Open access
- green
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