Measurement of human skeletal muscle oxidative capacity by 31 P‐MR spectroscopy: A cross‐validation with in vitro measurements

Lanza, Ian R.; Bhagra, Sumit; Nair, K. Sreekumaran; Port, John D.

doi:10.1002/jmri.22733

Cited by 103Advanced MRI Techniques and ApplicationsCardiovascular and exercise physiologyMuscle metabolism and nutrition

Measurement of human skeletal muscle oxidative capacity by 31 P‐MR spectroscopy: A cross‐validation with in vitro measurements

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Lanza, Ian R., Bhagra, Sumit, Nair, K. Sreekumaran, Port, John D.·2011·Journal of Magnetic Resonance Imaging

DOI 10.1002/jmri.22733PMC PMC3201762

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Abstract

Purpose: To cross‐validate skeletal muscle oxidative capacity measured by 31 P‐MR spectroscopy with in vitro measurements of oxidative capacity in mitochondria isolated from muscle biopsies of the same muscle group in 18 healthy adults. Materials and Methods: Oxidative capacity in vivo was determined from PCr recovery kinetics following a 30‐s maximal isometric knee extension. State 3 respiration was measured in isolated mitochondria using high‐resolution respirometry. A second cohort of 10 individuals underwent two 31 P‐MRS testing sessions to assess the test–retest reproducibility of the method. Results: Overall, the in vivo and in vitro methods were well‐correlated (r = 0.66–0.72) and showed good agreement by Bland Altman plots. Excellent reproducibility was observed for the PCr recovery rate constant (CV = 4.6%; ICC = 0.85) and calculated oxidative capacity (CV = 3.4%; ICC = 0.83). Conclusion: These results indicate that 31 P‐MRS corresponds well with gold‐standard in vitro measurements and is highly reproducible. J. Magn. Reson. Imaging 2011;. © 2011 Wiley Periodicals, Inc.

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Post-stimulation recovery kinetics of phosphocreatine can be used as an index of mitochondrial oxidative capacity in vivo.
“The post-stimulation recovery kinetics of phosphocreatine can be used as an index of the mitochondrial oxidative capacity in vivo (Arnold et al., 1984; Lanza et al., 2011).”
From Impaired aerobic capacity and premature fatigue preceding muscle weakness in the skeletal muscle Tfam-knockout mouse model (2021) · cites this paper as Lanza et al., 2011

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Authors: Lanza, I. R., Bhagra, S., Nair, K. S., & Port, J. D.
Affiliations: Mayo Clinic (US)
Corresponding author: Port, John D.
ORCID: Lanza, Ian R.
Bhagra, Sumit
Nair, K. Sreekumaran
Port, John D.
Venue: Journal of Magnetic Resonance Imaging
Publisher: Wiley
Published: 2011-08-16
Volume: 34
Issue: 5
Pages: 1143-1150
ISSN: 1053-1807 (ISSN-L)
1522-2586
DOI: 10.1002/jmri.22733
PMC: PMC3201762
OpenAlex: W2078374194
Cited by: 103
References: 32
Citations by year: 2026: 6 · 2025: 7 · 2024: 6 · 2023: 8 · 2022: 3 · 2021: 6 · 2020: 6 · 2019: 8 · 2018: 9 · 2017: 5 · 2016: 8 · 2015: 8 · 2014: 10 · 2013: 11 · 2012: 2
FWCI: 5.61
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Magnetic Resonance Imaging (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Mayo Clinic
National Institutes of Health (UL1-RR-025150)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK4197, R01DK041973)
National Center for Research Resources (KL2 RR02415, KL2RR024151, UL1-RR-025150, UL1RR024150)
Topics: Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Keywords: skeletal muscle oxidative capacity, 31P NMR, isolated mitochondria, state 3 respiration, high-resolution respirometry, cross-validation, test-retest reproducibility, muscle biopsy
MeSH terms: Adult, Biopsy, Female, Humans, Hydrogen-Ion Concentration, Knee, Male, Middle Aged, Mitochondria, Muscles, Magnetic Resonance Spectroscopy, Oxygen, Phosphocreatine, Phosphorus Isotopes, Reproducibility of Results, Cohort Studies, Oxidative Stress, Muscle, Skeletal, In Vitro Techniques

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Measurement of human skeletal muscle oxidative capacity by 31 P‐MR spectroscopy: A cross‐validation with in vitro measurements

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