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Cited by 493

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Identification of a membrane-associated interleukin 1 in macrophages.

Open access
Kurt-Jones, E A, Beller, D I, Mizel, S B, Unanue, E R·1985·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.82.4.1204
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Abstract

We have found a surface membrane-associated interleukin 1 (IL-1) with potent thymocyte and T-cell stimulatory activity on peptone-elicited peritoneal macrophages. The IL-1 activity was demonstrated on both fixed macrophage monolayers and on isolated membranes from unfixed macrophages. Membrane IL-1 was induced by adherence and/or by adding heat-killed Listeria monocytogenes to macrophage cultures. The macrophage membrane IL-1 was similar functionally and antigenically to soluble IL-1, but its expression could be temporally dissociated from IL-1 secretion; membrane IL-1 was induced earlier and persisted longer than IL-1 secretion during in vitro macrophage culture. Moreover, when cultured macrophages that had ceased both secretion and membrane expression of IL-1 were restimulated by adding heat-killed Listeria, substantial membrane IL-1 was induced in the absence of detectable IL-1 secretion. Membrane IL-1 appears to be an integral membrane protein since it was solubilized by detergent but was not eluted by EDTA, high salt, or low pH treatment of the membranes.

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Metadata

Authors
Kurt-Jones, E. A., Beller, D. I., Mizel, S. B., & Unanue, E. R.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
1985-02
Volume
82
Issue
4
Pages
1204-1208
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.82.4.1204
OpenAlex
W1995194119
Cited by
493
References
8
FWCI
16.47
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Identification of a membrane-associated interleukin 1 in macrophages. https://app.cochat.ai/papers/10.1073/pnas.82.4.1204
The paper
Kurt-Jones, E. A., Beller, D. I., Mizel, S. B., & Unanue, E. R. (1985). Identification of a membrane-associated interleukin 1 in macrophages. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.82.4.1204

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.