Immunological and inflammatory functions of the interleukin-1 family

IL-33, an Interleukin-1-like Cytokine that Signals via the IL-1 Receptor-Related Protein ST2 and Induces T Helper Type 2-Associated Cytokines

Schmitz, J., Owyang, A. M., Oldham, E. R., Song, Y., Murphy, E., McClanahan, T. K., Zurawski, G., Moshrefi, M., Qin, J., Li, X., et al. (2005) · Immunity · doi:10.1016/j.immuni.2005.09.015 · Cited by 3,701 · see citing works

Biologic basis for interleukin-1 in disease.

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Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.

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Cloning of a new cytokine that induces IFN-γ production by T cells

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Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17–producing human T helper cells

Acosta-Rodriguez, E. V., Napolitani, G., Lanzavecchia, A., & Sallusto, F. (2007) · Nature Immunology · doi:10.1038/ni1496 · Cited by 1,857 · see citing works

Interleukin-1-receptor antagonist in type 2 diabetes mellitus

Larsen, C. M., Faulenbach, M., Vaag, A., Vølund, A., Ehses, J. A., Seifert, B., Mandrup-Poulsen, T., & Donath, M. Y. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa065213 · Cited by 1,798 · see citing works

NALP3 Forms an IL-1β-Processing Inflammasome with Increased Activity in Muckle-Wells Autoinflammatory Disorder

Agostini, L., Martinon, F., Burns, K., McDermott, M. F., Hawkins, P. N., & Tschopp, J. (2004) · Immunity · doi:10.1016/s1074-7613(04)00046-9 · Cited by 1,768 · see citing works

Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle–Wells syndrome

Hoffman, H. M., Mueller, J. L., Broide, D. H., Wanderer, A. A., & Kolodner, R. D. (2001) · Nature Genetics · doi:10.1038/ng756 · Cited by 1,679 · see citing works

Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme

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Pannexin‐1 mediates large pore formation and interleukin‐1β release by the ATP‐gated P2X7 receptor

Pelegrı́n, P., & Surprenant, A. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601378 · Cited by 1,428 · see citing works

Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets

Maedler, K., Sergeev, P., Ris, F., Oberholzer, J., Joller‐Jemelka, H. I., Spinas, G. A., Kaiser, N., Halban, P. A., & Donath, M. Y. (2017) · Journal of Clinical Investigation · doi:10.1172/jci92172 · Cited by 1,114 · see citing works

IL-33 and ST2 comprise a critical biomechanically induced and cardioprotective signaling system

Sanada, S., Hakuno, D., Higgins, L., Schreiter, E. R., McKenzie, A. N. J., & Lee, R. T. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30634 · Cited by 1,053 · see citing works

IL-1 is required for tumor invasiveness and angiogenesis

Voronov, E., Shouval, D. S., Krelin, Y., Cagnano, E., Benharroch, D., Iwakura, Y., Dinarello, C. A., & Apte, R. N. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0437939100 · Cited by 1,023 · see citing works

A crucial role for interleukin (IL)-1 in the induction of IL-17–producing T cells that mediate autoimmune encephalomyelitis

Sutton, C. E., Brereton, C. F., Keogh, B., Mills, K. H. G., & Lavelle, E. C. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060285 · Cited by 1,009 · see citing works

Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets

Maedler, K., Sergeev, P., Ris, F., Oberholzer, J., Joller‐Jemelka, H. I., Spinas, G. A., Kaiser, N., Halban, P. A., & Donath, M. Y. (2002) · Journal of Clinical Investigation · doi:10.1172/jci200215318 · Cited by 1,006 · see citing works

Interleukin-1 Type II Receptor: A Decoy Target for IL-1 That Is Regulated by IL-4

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IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor <i>in vivo</i>

Carriere, V., Roussel, L., Ortega, N., Lacorre, D.-A., Americh, L., Aguilar, L., Bouche, G., & Girard, J.-P. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606854104 · Cited by 966 · see citing works

Altered Cytokine Production in Mice Lacking P2X7Receptors

Solle, M., Labasi, J. M., Perregaux, D. G., Stam, E. J., Petrushova, N., Koller, B. H., Griffiths, R., & Gabel, C. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006781200 · Cited by 924 · see citing works

Neonatal-Onset Multisystem Inflammatory Disease Responsive to Interleukin-1β Inhibition

Goldbach‐Mansky, R. T., Garnes, N. D., Canna, S., Gelabert, A., Jones, J. H., Rubin, B. I., Kim, H. J., Brewer, C. C., Zalewski, C. K., Wiggs, E. A., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa055137 · Cited by 923 · see citing works

Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade

Pascual, V., Allantaz, F., Arce, E., Punaro, M., & Banchereau, J. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050473 · Cited by 923 · see citing works

Identification of a key pathway required for the sterile inflammatory response triggered by dying cells

Chen, C.-J., Kono, H., Golenbock, D., Reed, G., Akira, S., & Rock, K. L. (2007) · Nature Medicine · doi:10.1038/nm1603 · Cited by 876 · see citing works

Inflammatory caspases and inflammasomes: master switches of inflammation

Martinon, F., & Tschopp, J. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402038 · Cited by 821 · see citing works

Development of Chronic Inflammatory Arthropathy Resembling Rheumatoid Arthritis in Interleukin 1 Receptor Antagonist–Deficient Mice

Horai, R., Saijo, S., Tanioka, H., Nakae, S., Sudo, K., Okahara, A., Ikuse, T., Asano, M., & Iwakura, Y. (2000) · Journal of Experimental Medicine · doi:10.1084/jem.191.2.313 · Cited by 792 · see citing works

Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain

Chessell, I. P., Hatcher, J. P., Bountra, C., Michel, A. D., Hughes, J. P., Green, P., Egerton, J., Murfin, M., Richardson, J. C., Peck, W. L., et al. (2005) · Pain · doi:10.1016/j.pain.2005.01.002 · Cited by 790 · see citing works

Differential requirement for the activation of the inflammasome for processing and release of IL-1β in monocytes and macrophages

Netea, M. G., Nold‐Petry, C. A., Nold, M. F., Joosten, L. A. B., Opitz, B., van der Meer, J. H. M., van de Veerdonk, F. L., Ferwerda, G., Heinhuis, B., Devesa, I., et al. (2008) · Blood · doi:10.1182/blood-2008-03-146720 · Cited by 787 · see citing works

Interleukin-18 Binding Protein

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A pilot study of IL-1 inhibition by anakinra in acute gout

So, A., De Smedt, T., Revaz, S., & Tschopp, J. (2007) · Arthritis Research &amp; Therapy · doi:10.1186/ar2143 · Cited by 727 · see citing works

De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal‐onset multisystem inflammatory disease (NOMID): A new member of the expanding family of pyrin‐associated autoinflammatory diseases

Aksentijevich, I. A., Nowak, M., Mallah, M., Chae, J. J., Watford, W. T., Hofmann, S. R., Stein, L. D., Russo, R. A. G., Goldsmith, D. P., Dent, P. B., et al. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10688 · Cited by 707 · see citing works

Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu

NAKANISHI, K., YOSHIMOTO, T., Tsutsui, H., & Okamura, H. (2001) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(00)00015-0 · Cited by 658 · see citing works

IL-33 reduces the development of atherosclerosis

Miller, A. M., Xu, D., Asquith, D. L., Denby, L., Li, Y., Sattar, N. A., Baker, A. H., McInnes, I. B., & Liew, F. Y. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20071868 · Cited by 642 · see citing works

A proinflammatory role for IL-18 in rheumatoid arthritis

Gracie, J. A., Forsey, R. J., Chan, W. L., Gilmour, A., Leung, B. P. L., Greer, M. R., Kennedy, K., Carter, R., Wei, X., Xu, D., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci7317 · Cited by 635 · see citing works

NF-κB Is a Negative Regulator of IL-1β Secretion as Revealed by Genetic and Pharmacological Inhibition of IKKβ

Greten, F. R., Arkan, M. C., Bollrath, J., Hsu, L.-C., Goode, J., Miething, C., Göktuna, S. I., Neuenhahn, M., Fierer, J., Paxian, S., et al. (2007) · Cell · doi:10.1016/j.cell.2007.07.009 · Cited by 616 · see citing works

Production of Mice Deficient in Genes for Interleukin (IL)-1α, IL-1β, IL-1α/β, and IL-1 Receptor Antagonist Shows that IL-1β Is Crucial in Turpentine-induced Fever Development and Glucocorticoid Secretion

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SIGIRR, a negative regulator of Toll-like receptor–interleukin 1 receptor signaling

Wald, D. N., Qin, J., Zhao, Z., Qian, Y., Naramura, M., Tian, L., Towne, J. E., Sims, J. E., Stark, G. R., & Li, X. (2003) · Nature Immunology · doi:10.1038/ni968 · Cited by 606 · see citing works

Efficacy and safety of rilonacept (interleukin‐1 trap) in patients with cryopyrin‐associated periodic syndromes: Results from two sequential placebo‐controlled studies

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Nonclassical IL-1β Secretion Stimulated by P2X7 Receptors Is Dependent on Inflammasome Activation and Correlated with Exosome Release in Murine Macrophages

Qu, Y., Franchi, L., Nunez, G., & Dubyak, G. R. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.3.1913 · Cited by 563 · see citing works

Interleukin 1 induces interleukin 1. I. Induction of circulating interleukin 1 in rabbits in vivo and in human mononuclear cells in vitro.

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Differential Regulation of Caspase-1 Activation, Pyroptosis, and Autophagy via Ipaf and ASC in Shigella-Infected Macrophages

Suzuki, T., Franchi, L., Toma, C., Ashida, H., Ogawa, M., Yoshikawa, Y., Mimuro, H., Inohara, N., Sasakawa, C., & Núñez, G. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030111 · Cited by 532 · see citing works

Cytotoxicity of Human p I 7 Interleukin-1 for Pancreatic Islets of Langerhans

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Pannexin-1-Mediated Recognition of Bacterial Molecules Activates the Cryopyrin Inflammasome Independent of Toll-like Receptor Signaling

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IL-1 Receptor Accessory Protein and ST2 Comprise the IL-33 Receptor Complex

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Identification of a membrane-associated interleukin 1 in macrophages.

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IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist

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The Secretory Route of the Leaderless Protein Interleukin 1β Involves Exocytosis of Endolysosome-related Vesicles

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Purification and Characterization of the Human Interleukin-18 Receptor

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A randomised phase II study of interleukin-1 receptor antagonist in acute stroke patients

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Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance

Netea, M. G., Joosten, L. A. B., Lewis, E., Jensen, D. R., Voshol, P. J., Kullberg, B. J., Tack, C. J., van Krieken, H., Kim, S.-H., Stalenhoef, A. F., et al. (2006) · Nature Medicine · doi:10.1038/nm1415 · Cited by 424 · see citing works

Interleukin (IL)-1F6, IL-1F8, and IL-1F9 Signal through IL-1Rrp2 and IL-1RAcP to Activate the Pathway Leading to NF-κB and MAPKs

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Targeted Disruption of Pyrin, the FMF Protein, Causes Heightened Sensitivity to Endotoxin and a Defect in Macrophage Apoptosis

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Phospholipases C and A 2 control lysosome-mediated IL-1β secretion: Implications for inflammatory processes

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Resistance to fever induction and impaired acute-phase response in interleukin-1 beta-deficient mice.

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Gene expression, synthesis, and secretion of interleukin 18 and interleukin 1β are differentially regulated in human blood mononuclear cells and mouse spleen cells

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The type II ‘decoy’ receptor: A novel regulatory pathway for interleukin 1

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Association of mutations in the NALP3/CIAS1/PYPAF1 gene with a broad phenotype including recurrent fever, cold sensitivity, sensorineural deafness, and AA amyloidosis

Aganna, E., Martinon, F., Hawkins, P. N., Ross, J. B., Swan, D., Booth, D. R., Lachmann, H. J., Gaudet, R., Woo, P. M., Feighery, C., et al. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10509 · Cited by 367 · see citing works

Converting enzyme-independent release of tumor necrosis factor α and IL-1β from a stimulated human monocytic cell line in the presence of activated neutrophils or purified proteinase 3

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Cytokine traps: multi-component, high-affinity blockers of cytokine action

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IL-6-dependent and -independent pathways in the development of interleukin 17-producing T helper cells

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Rapid responses to anakinra in patients with refractory adult‐onset Still's disease

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The precursor form of IL-1α is an intracrine proinflammatory activator of transcription

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Mechanisms of caspase-1 activation by P2X7 receptor-mediated K+ release

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Cloning of a Novel Receptor Subunit, AcPL, Required for Interleukin-18 Signaling

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IL-1 receptor accessory protein is essential for IL-33-induced activation of T lymphocytes and mast cells

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Affinity-purified human Interleukin I is cytotoxic to isolated islets of Langerhans

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Increased Interleukin (IL)-1β Messenger Ribonucleic Acid Expression in β-Cells of Individuals with Type 2 Diabetes and Regulation of IL-1β in Human Islets by Glucose and Autostimulation

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Arterial Inflammation in Mice Lacking the Interleukin 1 Receptor Antagonist Gene

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Functions of interleukin 1 receptor antagonist in gene knockout and overproducing mice.

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Alternative promoter usage of the Fos‐responsive gene Fit‐1 generates mRNA isoforms coding for either secreted or membrane‐bound proteins related to the IL‐1 receptor.

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Th17 cells: a new fate for differentiating helper T cells

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A new member of the IL-1 receptor family highly expressed in hippocampus and involved in X-linked mental retardation

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Neutrophil Proteinase 3-Mediated Induction of Bioactive IL-18 Secretion by Human Oral Epithelial Cells

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Severe imbalance of IL-18/IL-18BP in patients with secondary hemophagocytic syndrome

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IL-1β mediates leptin induction during inflammation.

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Two Novel IL-1 Family Members, IL-1δ and IL-1ε, Function as an Antagonist and Agonist of NF-κB Activation Through the Orphan IL-1 Receptor-Related Protein 2

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Interleukin-1β–Driven Inflammation Promotes the Development and Invasiveness of Chemical Carcinogen–Induced Tumors

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A NOVEL IL-18BP ELISA SHOWS ELEVATED SERUM IL-18BP IN SEPSIS AND EXTENSIVE DECREASE OF FREE IL-18

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IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE/stat6 under specific pathogen-free conditions

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Caspase-1-dependent processing of pro-interleukin-1β is cytosolic and precedes cell death

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ATP Acts as an Agonist to Promote Stimulus-Induced Secretion of IL-1β and IL-18 in Human Blood

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Intestinal inflammation in mice deficient in Tir8 , an inhibitory member of the IL-1 receptor family

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A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity

Bufler, P., Azam, T., Gamboni-Robertson, F., Reznikov, L. L., Kumar, S., Dinarello, C. A., & Kim, S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.212519099 · Cited by 252 · see citing works

Pattern of interleukin‐1β secretion in response to lipopolysaccharide and ATP before and after interleukin‐1 blockade in patients with CIAS1 mutations

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Caspase-1-Independent, Fas/Fas Ligand–Mediated IL-18 Secretion from Macrophages Causes Acute Liver Injury in Mice

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The IL-1 Family Member 7b Translocates to the Nucleus and Down-Regulates Proinflammatory Cytokines

Sharma, S., Kulk, N., Nold, M. F., Gräf, R., Kim, S., Reinhardt, D., Dinarello, C. A., & Bufler, P. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.8.5477 · Cited by 242 · see citing works

The IL-1 Receptor-Related T1 Antigen Is Expressed on Immature and Mature Mast Cells and on Fetal Blood Mast Cell Progenitors

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Response to local inflammation of IL-1 beta-converting enzyme- deficient mice

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Dissociation between interleukin-1 beta mRNA and protein synthesis in human peripheral blood mononuclear cells.

Schindler, R., Clark, B. D., & Dinarello, C. A. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)86936-8 · Cited by 228 · see citing works

SIGIRR Inhibits Interleukin-1 Receptor- and Toll-like Receptor 4-mediated Signaling through Different Mechanisms

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IL-1Rrp Is a Novel Receptor-like Molecule Similar to the Type I Interleukin-1 Receptor and Its Homologues T1/ST2 and IL-1R AcP

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Cloning and Characterization of IL-1HY2, a Novel Interleukin-1 Family Member

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SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1-dependent inflammatory arthritis

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Potentiation of Caspase-1 Activation by the P2X7 Receptor Is Dependent on TLR Signals and Requires NF-κB-Driven Protein Synthesis

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T1/ST2 Signaling Establishes It as a Member of an Expanding Interleukin-1 Receptor Family

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IL-1H, AN INTERLEUKIN 1-RELATED PROTEIN THAT BINDS IL-18 RECEPTOR/IL-1Rrp

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Interleukin-1 induces interleukin-8 secretion from endothelial cells by a juxtacrine mechanism

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MEFV mutation analysis in patients suffering from amyloidosis of familial Mediterranean fever

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Therapeutic strategies to reduce IL-1 activity in treating local and systemic inflammation

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Effect of endotoxin in IL-1 β-deficient mice

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IL-12–induced IFN-γ is dependent on caspase-1 processing of the IL-18 precursor

Fantuzzi, G., Reed, D. A., & Dinarello, C. A. (1999) · Journal of Clinical Investigation · doi:10.1172/jci7501 · Cited by 189 · see citing works

Identification and Gene Organization of Three Novel Members of the IL-1 Family on Human Chromosome 2

Busfield, S. J., Comrack, C. A., Yu, G., Chickering, T. W., Smutko, J. S., Zhou, H., Leiby, K. R., Holmgren, L. M., Gearing, D. P., & Pan, Y. (2000) · Genomics · doi:10.1006/geno.2000.6184 · Cited by 173 · see citing works

IL-1 Receptor Accessory Protein Is an Essential Component of the IL-1 Receptor

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Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency

Zorrilla, E. P., Sánchez-Alavez, M., Sugama, S., Brennan, M., Fernandez, R. E., Bartfai, T., & Conti, B. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611523104 · Cited by 170 · see citing works

A Novel Therapy of Murine Collagen-Induced Arthritis with Soluble T1/ST2

Leung, B. P. L., Xu, D., Culshaw, S., McInnes, I. B., & Liew, F. Y. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.1.145 · Cited by 168 · see citing works

Interleukin-1 homologues IL-1F7b and IL-18 contain functional mRNA instability elements within the coding region responsive to lipopolysaccharide

Bufler, P., Gamboni-Robertson, F., Azam, T., Kim, S., & Dinarello, C. A. (2004) · Biochemical Journal · doi:10.1042/bj20040217 · Cited by 162 · see citing works

Interleukin 18–independent engagement of interleukin 18 receptor-α is required for autoimmune inflammation

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Glu496 to Ala Polymorphism in the P2X7 Receptor Impairs ATP-Induced IL-1β Release from Human Monocytes

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Interleukin‐1β, but not interleukin‐1α, is required for T‐cell‐dependent antibody production

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Mechanisms of Inhibition of Collagen-Induced Arthritis by Murine IL-18 Binding Protein

Banda, N. K., Vondracek, A., Kraus, D., Dinarello, C. A., Kim, S., Bendele, A. M., Senaldi, G., & Arend, W. P. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.4.2100 · Cited by 146 · see citing works

The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes

Magne, D., Palmer, G., Barton, J. L., Mézin, F., Talabot‐Ayer, D., Bas, S., Duffy, T., Noger, M., Guerne, P., Nicklin, M. J. H., et al. (2006) · Arthritis Research & Therapy · doi:10.1186/ar1946 · Cited by 146 · see citing works

Glucose- and Interleukin-1β-Induced β-Cell Apoptosis Requires Ca2+ Influx and Extracellular Signal-Regulated Kinase (ERK) 1/2 Activation and Is Prevented by a Sulfonylurea Receptor 1/Inwardly Rectifying K+ Channel 6.2 (SUR/Kir6.2) Selective Potassium Channel Opener in Human Islets

Maedler, K., Størling, J., Sturis, J., Zuellig, R. A., Spinas, G. A., Arkhammar, P. O. G., Mandrup-Poulsen, T. R., & Donath, M. Y. (2004) · Diabetes · doi:10.2337/diabetes.53.7.1706 · Cited by 146 · see citing works

HMG-1 REDISCOVERED AS A CYTOKINE

Yang, H., Wang, H., & Tracey, K. J. (2001) · Shock · doi:10.1097/00024382-200115040-00001 · Cited by 145 · see citing works

Abnormal T cell activation caused by the imbalance of the IL-1/IL-1R antagonist system is responsible for the development of experimental autoimmune encephalomyelitis.

Matsuki, T., Nakae, S., Sudo, K., Horai, R., & Iwakura, Y. (2006) · International Immunology · doi:10.1093/intimm/dxh379 · Cited by 142 · see citing works

Identification of a Novel Human Cytokine Gene in the Interleukin Gene Cluster on Chromosome 2q12-14

Bensen, J. T., Dawson, P. A., Mychaleckyj, J. C., & Bowden, D. W. (2001) · Journal of Interferon & Cytokine Research · doi:10.1089/107999001753289505 · Cited by 141 · see citing works

Pathogenesis of familial periodic fever syndromes or hereditary autoinflammatory syndromes

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A short synthetic peptide fragment of human interleukin 1 with immunostimulatory but not inflammatory activity.

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Cutting Edge: IL-18-Transgenic Mice: In Vivo Evidence of a Broad Role for IL-18 in Modulating Immune Function

Hoshino, T., Kawase, Y., Okamoto, M., Yokota, K., Yoshino, K., Yamamura, K., Miyazaki, J., Young, H. A., & Ōizumi, K. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.12.7014 · Cited by 135 · see citing works

The Interleukin‐1 Receptor Family

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Endogenous interleukin 1 alpha must be transported to the nucleus to exert its activity in human endothelial cells.

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Resistant Behçet Disease Responsive to Anakinra

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IL-1 induces IL-1. IV. IFN-gamma suppresses IL-1 but not lipopolysaccharide-induced transcription of IL-1.

Schindler, R., Ghezzi, P., & Dinarello, C. A. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.144.6.2216 · Cited by 129 · see citing works

Interleukin-1 receptor antagonist in normal and psoriatic epidermis.

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A Key Role for Redox Signaling in Rapid P2X7 Receptor-Induced IL-1β Processing in Human Monocytes

Hewinson, J., Moore, S., Glover, C., Watts, A. G., & Mackenzie, A. B. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.12.8410 · Cited by 122 · see citing works

IFN-γ-Dependent and -Independent Mechanisms in Adverse Effects Caused by Concomitant Administration of IL-18 and IL-12

Nakamura, S., Otani, T., Ijiri, Y., Motoda, R., Kurimoto, M., & Orita, K. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.6.3330 · Cited by 113 · see citing works

The N-terminal propiece of interleukin 1α is a transforming nuclear oncoprotein

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Activation induces rapid and profound alterations in the trafficking of T cells

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Differential role and tissue specificity of interleukin-1α gene expression in atherogenesis and lipid metabolism

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The many worlds of reducing interleukin‐1

Dinarello, C. A. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21107 · Cited by 104 · see citing works

Recombinant human interleukin‐1 receptor type I in the treatment of patients with active rheumatoid arthritis

Drevlow, B. E., Lovis, R. M., Haag, M. A., Sinacore, J. M., Jacobs, C. A., Blosche, C., LANDAY, A. L., Moreland, L. W., & Pope, R. M. (1996) · Arthritis & Rheumatism · doi:10.1002/art.1780390212 · Cited by 103 · see citing works

P2X7 receptor polymorphism impairs extracellular adenosine 5′-triphosphate-induced interleukin-18 release from human monocytes

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IL1HY1: A Novel Interleukin-1 Receptor Antagonist Gene

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Prevention of IL-1 signaling attenuates airway hyperresponsiveness and inflammation in a murine model of toluene diisocyanate–induced asthma

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Innate Immunity Mediated by the Cytokine IL-1 Homologue 4 (IL-1H4/IL-1F7) Induces IL-12-Dependent Adaptive and Profound Antitumor Immunity

Gao, W., Kumar, S., Lotze, M. T., Hanning, C. R., Robbins, P. D., & Gambotto, A. A. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.1.107 · Cited by 92 · see citing works

Pharmacokinetics of IL-18 binding protein in healthy volunteers and subjects with rheumatoid arthritis or plaque psoriasis

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Functional Reconstitution and Regulation of IL-18 Activity by the IL-18Rβ Chain

Kim, S. H., Reznikov, L. L., Stuyt, R. J. L., Selzman, C. H., Fantuzzi, G., Hoshino, T., Young, H. A., & Dinarello, C. A. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.1.148 · Cited by 86 · see citing works

Intracellular IL-1α-binding proteins contribute to biological functions of endogenous IL-1α in systemic sclerosis fibroblasts

Kawaguchi, Y., Nishimagi, E., Tochimoto, A., Kawamoto, M., Katsumata, Y., Soejima, M., Kanno, T., Kamatani, N., & Hara, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603545103 · Cited by 85 · see citing works

SIGIRR Promotes Resistance against Pseudomonas aeruginosa Keratitis by Down-Regulating Type-1 Immunity and IL-1R1 and TLR4 Signaling

Huang, X., Hazlett, L. D., Du, W., & Barrett, R. P. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.1.548 · Cited by 81 · see citing works

Development of a Novel Noncompetitive Antagonist of IL-1 Receptor

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IL‐1F5 mediates anti‐inflammatory activity in the brain through induction of IL‐4 following interaction with SIGIRR/TIR8

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Interleukin‐1 receptor accessory protein interacts with the type II interleukin‐1 receptor

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Interleukin-18, together with interleukin-12, induces severe acute pancreatitis in obese but not in nonobese leptin-deficient mice

Sennello, J. A., Fayad, R., Pini, M., Gove, M. E., Ponemone, V., Cabay, R. J., Siegmund, B., Dinarello, C. A., & Fantuzzi, G. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804091105 · Cited by 79 · see citing works

The Membrane Form of the Type II IL-1 Receptor Accounts for Inhibitory Function

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Peripheral blood mononuclear cells stimulated with C5a or lipopolysaccharide to synthesize equivalent levels of IL-1 beta mRNA show unequal IL-1 beta protein accumulation but similar polyribosome profiles.

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Correspondence of the Functional Epitopes of Poxvirus and Human Interleukin-18-Binding Proteins

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Cytokines in human renal interstitial fibrosis. II. Intrinsic interleukin (IL)-1 synthesis and IL-1-dependent production of IL-6 and IL-8 by cultured kidney fibroblasts

Lonnemann, G., Engler-Blum, G., Muller, G. A., Koch, K. M., & Dubarello, C. A. (1995) · Kidney International · doi:10.1038/ki.1995.127 · Cited by 71 · see citing works

Cutting Edge: IL-1 Controls the IL-23 Response Induced by Gliadin, the Etiologic Agent in Celiac Disease

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Identification of the promoter region of human interleukin 1 type I receptor gene: multiple initiation sites, high G+C content, and constitutive expression.

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Identification of Amino Acid Residues Critical for Biological Activity in Human Interleukin-18

Kim, S., Azam, T., Novick, D., Yoon, D., Reznikov, L. L., Bufler, P., Rubinstein, M., & Dinarello, C. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108311200 · Cited by 63 · see citing works

Mutations in cryopyrin: Bypassing roadblocks in the caspase 1 inflammasome for interleukin‐1β secretion and disease activity

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IL-33: A Sheep in Wolf’s Clothing?

Gadina, M., & Jefferies, C. A. (2007) · Science s STKE · doi:10.1126/stke.3902007pe31 · Cited by 57 · see citing works

Antiviral and immunoregulatory activities of IFN-γ depend on constitutively expressed IL-1α

Hurgin, V., Novick, D., Werman, A., Dinarello, C. A., & Rubinstein, M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611608104 · Cited by 57 · see citing works

Responses of IL-18- and IL-18 receptor-deficient pancreatic islets with convergence of positive and negative signals for the IL-18 receptor

Lewis, E. C., & Dinarello, C. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607917103 · Cited by 55 · see citing works

Phosphorylation of IRF8 in a pre-associated complex with Spi-1/PU.1 and non-phosphorylated Stat1 is critical for LPS induction of the IL1B gene

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Different patterns of interleukin-1alpha and interleukin-1beta expression in organs of normal young and old mice.

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Adenovirus expressing interleukin-1 receptor antagonist alleviates allergic airway inflammation in a murine model of asthma

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Protective Effect of IL-18 on Kainate- and IL-1β-Induced Cerebellar Ataxia in Mice

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