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Cited by 313

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Protection against gram-negative bacteremia and endotoxemia with human monoclonal IgM antibodies.

Open access
Teng, N N, Kaplan, H S, Hebert, J M, Moore, C, Douglas, H, Wunderlich, A, Braude, A I·1985·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.82.6.1790
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Abstract

Hybridomas producing human monoclonal IgM antibodies (mAbs) against bacterial lipopolysaccharide (LPS) were generated by fusion of B lymphocytes from sensitized human spleen with heteromyeloma cells. The splenocytes were from patients undergoing splenectomy during staging for Hodgkin disease after vaccination with the J5 mutant of Escherichia coli, which is deficient in O antigenic side chains. This deficiency exposes the core oligosaccharide, common to LPS of all Gram-negative bacteria. The mAbs cross-reacted strongly with endotoxins from a wide range of unrelated species of Gram-negative bacteria. The mAbs also gave strong protection against LPS in the dermal Shwartzman reaction and against lethal Gram-negative bacteremia in mice. These findings indicate that monoclonal IgM against LPS endotoxin can neutralize its toxicity in vivo and might be valuable for treatment of patients with Gram-negative bacteremia. Analysis of one of the hybridoma clones, A6(H4C5), showed that the IgM mAb is directed against the covalently bound lipid A, which represents the most conservative and least variable structural element of LPS.

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Metadata

Authors
Teng, N. N., Kaplan, H. S., Hebert, J. M., Moore, C., Douglas, H., Wunderlich, A., & Braude, A. I.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
1985-03
Volume
82
Issue
6
Pages
1790-1794
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.82.6.1790
OpenAlex
W2064107559
Cited by
313
References
9
FWCI
22.59
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Protection against gram-negative bacteremia and endotoxemia with human monoclonal IgM antibodies. https://app.cochat.ai/papers/10.1073/pnas.82.6.1790
The paper
Teng, N. N., Kaplan, H. S., Hebert, J. M., Moore, C., Douglas, H., Wunderlich, A., & Braude, A. I. (1985). Protection against gram-negative bacteremia and endotoxemia with human monoclonal IgM antibodies. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.82.6.1790

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.