The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Location of the major antigenic sites involved in rotavirus serotype-specific neutralization.
Open accessAbstract
Antigenic sites on the rotavirus major outershell glycoprotein were identified by using mutant viruses selected for resistance to neutralizing (serotype-specific) monoclonal antibodies. The glycoprotein genes from these mutants were sequenced to determine the position and nature of the resultant amino acid substitutions in the protein. Three regions (A, B, and C) were identified (amino acids 87-96, 145-150, and 211-223, respectively), of which region C appears to be the most important. A mutation in region C caused a 10-fold increase in resistance to neutralization by polyclonal antiviral antiserum. The results of this study, together with other data, indicate that the three-dimensional folding of the native protein is such that regions A and C are in close proximity.
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Citations
Cites
Priming for and induction of anti-poliovirus neutralizing antibodies by synthetic peptides
Emini, E. A., Jameson, B. A., & Wimmer, E. (1983) · Nature · doi:10.1038/304699a0 · Cited by 237
Cited by
A semi‐empirical method for prediction of antigenic determinants on protein antigens
Kolaskar, A. S., & Tongaonkar, P. C. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)80535-q · Cited by 1,439
Rotavirus gene structure and function.
Estes, M. K., & Cohen, J. (1989) · Microbiological Reviews · doi:10.1128/mmbr.53.4.410-449.1989 · Cited by 885
Metadata
- Authors
- Dyall-Smith, M. L., Lazdins, I., Tregear, G. W., & Holmes, I. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1986-05
- Volume
- 83
- Issue
- 10
- Pages
- 3465-3468
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2070296246
- Cited by
- 239
- References
- 1
- FWCI
- 12.93
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Location of the major antigenic sites involved in rotavirus serotype-specific neutralization. https://app.cochat.ai/papers/10.1073/pnas.83.10.3465
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- Dyall-Smith, M. L., Lazdins, I., Tregear, G. W., & Holmes, I. H. (1986). Location of the major antigenic sites involved in rotavirus serotype-specific neutralization. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.83.10.3465
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
