The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
A semi‐empirical method for prediction of antigenic determinants on protein antigens
Abstract
Analysis of data from experimentally determined antigenic sites on proteins has revealed that the hydrophobic residues Cys, Leu and Val, if they occur on the surface of a protein, are more likely to be a part of antigenic sites. A semi‐empirical method which makes use of physicochemical properties of amino acid residues and their frequencies of occurrence in experimentally known segmental epitopes was developed to predict antigenic determinants on proteins. Application of this method to a large number of proteins has shown that our method can predict antigenic determinants with about 75% accuracy which is better than most of the known methods. This method is based on a single parameter and thus very simple to use.
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Cites
Prediction of protein antigenic determinants from amino acid sequences.
Hopp, T. P., & Woods, K. R. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.6.3824 · Cited by 3,705
Parker, J. M. R., Guo, D., & Hodges, R. S. (1986) · Biochemistry · doi:10.1021/bi00367a013 · Cited by 1,185
Prediction of sequential antigenic regions in proteins
Welling, G. W., Weijer, W. J., van der Zee, R., & Welling-Wester, S. (1985) · FEBS Letters · doi:10.1016/0014-5793(85)80374-4 · Cited by 353
Location of the major antigenic sites involved in rotavirus serotype-specific neutralization.
Dyall-Smith, M. L., Lazdins, I., Tregear, G. W., & Holmes, I. H. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.10.3465 · Cited by 239
The Chemistry and Mechanism of Antibody Binding to Protein Antigens
Getzoff, E. D., Tainer, J. A., Lerner, R. A., & Geysen, H. M. (1988) · Advances in Immunology · doi:10.1016/s0065-2776(08)60363-6 · Cited by 213
Synthetic T and B Cell Recognition Sites: Implications for Vaccine Development
Milich, D. R. (1989) · Advances in immunology · doi:10.1016/s0065-2776(08)60694-x · Cited by 86
Development and application of synthetic peptides as vaccines
Schmidt, M. A. (1989) · Biotechnology Advances · doi:10.1016/0734-9750(89)90358-3 · Cited by 10
Cited by
Prediction of continuous B‐cell epitopes in an antigen using recurrent neural network
Saha, S., & Raghava, G. P. S. (2006) · Proteins: Structure, Function, and Bioinformatics · doi:10.1002/prot.21078 · Cited by 1,747
Fundamentals and Methods for T- and B-Cell Epitope Prediction
Sanchez-Trincado, J. L., Gomez-Perosanz, M., & Reche, P. A. (2017) · Journal of Immunology Research · doi:10.1155/2017/2680160 · Cited by 674
Prediction of linear B-cell epitopes using amino acid pair antigenicity scale
Chen, J., Liu, H., Yang, J., & Chou, K.-C. (2007) · Amino Acids · doi:10.1007/s00726-006-0485-9 · Cited by 552
High-throughput prediction of protein antigenicity using protein microarray data
Magnan, C. N., Zeller, M., Kayala, M. A., Vigil, A., Randall, A., Felgner, P. L., & Baldi, P. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq551 · Cited by 531
Saha, S., & Raghava, G. P. S. (2004) · Lecture Notes in Computer Science · doi:10.1007/978-3-540-30220-9_16 · Cited by 443
Metadata
- Authors
- Kolaskar, A. S., & Tongaonkar, P. C.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1990-12-10
- Volume
- 276
- Issue
- 1-2
- Pages
- 172-174
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2066609648
- Cited by
- 1,439
- References
- 7
- FWCI
- 0.27
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kolaskar, A. S., & Tongaonkar, P. C. (1990). A semi‐empirical method for prediction of antigenic determinants on protein antigens. FEBS Letters. https://doi.org/10.1016/0014-5793(90)80535-q
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
