The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Design of potent, orally effective, nonpeptidal antagonists of the peptide hormone cholecystokinin.
Open accessAbstract
We describe the design and synthesis of nonpeptidal antagonists of the peptide hormone cholecystokinin. Several of these compounds have high specificity and nanomolar binding affinity and are active after oral administration. To our knowledge, the design of such agents has not previously been accomplished for any peptide hormone. The structural similarities between these synthetic compounds and the anxiolytic 1,4-benzodiazepines are noted, and the potential of this structural feature for future design of ligands for other peptide hormone receptors is discussed.
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Citations
Cites
Identification of two related pentapeptides from the brain with potent opiate agonist activity
Hughes, J., Smith, T. W., Kosterlitz, H. W., Fothergill, L. A., Morgan, B. A., & Morris, H. R. (1975) · Nature · doi:10.1038/258577a0 · Cited by 3,806
Cited by
Evans, B. E., Rittle, K. E., Bock, M. G., DiPardo, R. M., Freidinger, R. M., Whitter, W. L., Lundell, G. F., Veber, D. F., Anderson, P. S., Chang, R. S. L., et al. (1988) · Journal of Medicinal Chemistry · doi:10.1021/jm00120a002 · Cited by 1,456
Self-citationLotti, V. J., & Chang, R. S. L. (1989) · European Journal of Pharmacology · doi:10.1016/0014-2999(89)90290-2 · Cited by 398
The combinatorial synthesis and chemical and biological evaluation of a 1,4-benzodiazepine library.
Bunin, B. A., Plunkett, M. J., & Ellman, J. A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.11.4708 · Cited by 260
KARLSSON, S., & AHRÉN, B. (1989) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1989.tb08577.x · Cited by 20
Metadata
- Authors
- Evans, B. E., Bock, M. G., Rittle, K. E., DiPardo, R. M., Whitter, W. L., Veber, D. F., Anderson, P. S., & Freidinger, R. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1986-07
- Volume
- 83
- Issue
- 13
- Pages
- 4918-4922
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2123092430
- Cited by
- 327
- References
- 1
- FWCI
- 10.22
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Evans, B. E., Bock, M. G., Rittle, K. E., DiPardo, R. M., Whitter, W. L., Veber, D. F., Anderson, P. S., & Freidinger, R. M. (1986). Design of potent, orally effective, nonpeptidal antagonists of the peptide hormone cholecystokinin. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.83.13.4918
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
