The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
The combinatorial synthesis and chemical and biological evaluation of a 1,4-benzodiazepine library.
Open accessAbstract
A library of 192 structurally diverse 1,4-benzodiazepine derivatives containing a variety of chemical functionalities including amides, carboxylic acids, amines, phenols, and indoles was constructed from three components, 2-aminobenzophenones, amino acids, and alkylating agents, by employing Geysen's pin apparatus [Geysen, H. M., Rodda, S. J., Mason, T. J., Tribbick, G. & Schoofs, P. G. (1987) J. Immunol. Methods 102, 259-274]. Rigorous analytical verification of the chemical integrity and yield of a representative collection of the diverse derivatives was carried out. In addition, the library of derivatives was evaluated for binding to the cholecystokinin A receptor by employing a competitive radio-ligand binding assay. This provided detailed structure versus activity relationships that were confirmed by independent large-scale synthesis and evaluation of several of the 1,4-benzodiazepine derivatives.
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Cited by
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Metadata
- Authors
- Bunin, B. A., Plunkett, M. J., & Ellman, J. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1994-05-24
- Volume
- 91
- Issue
- 11
- Pages
- 4708-4712
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1983646492
- Cited by
- 260
- References
- 17
- FWCI
- 23.72
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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