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Isolation, properties, and complete amino acid sequence of human secretory leukocyte protease inhibitor, a potent inhibitor of leukocyte elastase.
Open accessAbstract
A potent inhibitor of human leukocyte elastase (EC 3.4.21.37) and cathepsin G (EC 3.4.21.20) and of human trypsin (EC 3.4.21.4) has been purified from human parotid secretions. The complete amino acid sequence of this protein has been determined. The sequence suggests that the protein has two domains of about 54 amino acids, each of which contains four disulfide bonds. On the basis of a limited homology to other protease inhibitors, the antielastase and antitrypsin activities are thought to be properties of the C-terminal and N-terminal domains, respectively. The affinity of the inhibitor for leukocyte elastase is very high, suggesting a functional role for the protein in preventing elastase-mediated damage to oral and possibly other mucosal tissues.
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Citations
Cited by
Tissue Destruction by Neutrophils
Epstein, F. H., & Weiss, S. J. (1989) · New England Journal of Medicine · doi:10.1056/nejm198902093200606 · Cited by 3,950
Wiedow, O., Schröder, J. M., Gregory, H., Young, J. A., & Christophers, E. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)77182-2 · Cited by 433
McElvaney, N. G., Nakamura, H., Birrer, P., Hébert, C. A., Wong, W. L., Alphonso, M., Baker, J. B., Catalano, M. A., & Crystal, R. G. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115994 · Cited by 299
McNeely, T. B., Shugars, D. C., Rosendahl, M., Tucker, C., Eisenberg, S. P., & Wahl, S. M. (1997) · Blood · doi:10.1182/blood.v90.3.1141 · Cited by 253
Regulation of Proteolysis at the Neutrophil-Substrate Interface by Secretory Leukoprotease Inhibitor
Rice, W. G., & Weiss, S. J. (1990) · Science · doi:10.1126/science.2371565 · Cited by 165
Metadata
- Authors
- Thompson, R. C., & Ohlsson, K.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1986-09
- Volume
- 83
- Issue
- 18
- Pages
- 6692-6696
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2024882709
- Cited by
- 475
- References
- 0
- FWCI
- 3.38
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Isolation, properties, and complete amino acid sequence of human secretory leukocyte protease inhibitor, a potent inhibitor of leukocyte elastase. https://app.cochat.ai/papers/10.1073/pnas.83.18.6692
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- Thompson, R. C., & Ohlsson, K. (1986). Isolation, properties, and complete amino acid sequence of human secretory leukocyte protease inhibitor, a potent inhibitor of leukocyte elastase. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.83.18.6692
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