The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Modulation of airway inflammation in cystic fibrosis. In vivo suppression of interleukin-8 levels on the respiratory epithelial surface by aerosolization of recombinant secretory leukoprotease inhibitor.
Open accessAbstract
Based on the knowledge that neutrophil elastase (NE) in cystic fibrosis (CF) epithelial lining fluid (ELF) can induce human bronchial epithelial cells to express the gene for interleukin 8 (IL-8), an 8.5-kD neutrophil chemoattractant, we have evaluated CF ELF for the presence of IL-8, and investigated the ability of aerosolized recombinant secretory leukoprotease inhibitor (rSLPI) to suppress NE, and hence IL-8, levels on the respiratory epithelial surface in CF. Enzyme-linked immunoassay revealed 21.9 +/- 4.8 nM IL-8 in CF ELF compared with none in normals. Active NE was detectable in ELF of all individuals with CF and was significantly decreased (P < 0.03) after aerosolization of rSLPI. Human bronchial epithelial cells exposed to CF ELF recovered before rSLPI therapy expressed IL-8 mRNA transcripts, but ELF recovered after rSLPI therapy induced far less bronchial epithelial cell IL-8 gene expression. Consistent with this, rSLPI aerosol therapy caused a marked reduction in CF ELF IL-8 levels (P < 0.05) and neutrophil number (P < 0.02). There was also a clear association between CF ELF active NE and IL-8 levels (r = 0.94). These data suggest that rSLPI therapy not only suppresses respiratory epithelial NE levels, but also breaks a cycle of inflammation on the CF epithelial surface.
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Cites
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Cited by
Ratjen, F., & Döring, G. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12567-6 · Cited by 885
Taggart, C., Cervantes-Laurean, D., Kim, G., McElvaney, N. G., Wehr, N., Moss, J., & Levine, R. L. (2000) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)61505-x · Cited by 269
Self-citationRogan, M. P., Taggart, C. C., Greene, C. M., Murphy, P. G., O’Neill, S. J., & McElvaney, N. G. (2004) · The Journal of Infectious Diseases · doi:10.1086/423821 · Cited by 171
Self-citationOxidized mucus proteinase inhibitor: a fairly potent neutrophil elastase inhibitor
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Nobar, S. M., Zani, M., Boudier, C., Moreau, T., & Bieth, J. G. (2005) · The FEBS Journal · doi:10.1111/j.1742-4658.2005.04988.x · Cited by 27
Metadata
- Authors
- McElvaney, N. G., Nakamura, H., Birrer, P., Hébert, C. A., Wong, W. L., Alphonso, M., Baker, J. B., Catalano, M. A., & Crystal, R. G.
- Venue
- Journal of Clinical Investigation
- Published
- 1992-10-01
- Volume
- 90
- Issue
- 4
- Pages
- 1296-1301
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2132347745
- Cited by
- 299
- References
- 37
- FWCI
- 19.97
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Modulation of airway inflammation in cystic fibrosis. In vivo suppression of interleukin-8 levels on the respiratory epithelial surface by aerosolization of recombinant secretory leukoprotease inhibitor. https://app.cochat.ai/papers/10.1172/jci115994
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- McElvaney, N. G., Nakamura, H., Birrer, P., Hébert, C. A., Wong, W. L., Alphonso, M., Baker, J. B., Catalano, M. A., & Crystal, R. G. (1992). Modulation of airway inflammation in cystic fibrosis. In vivo suppression of interleukin-8 levels on the respiratory epithelial surface by aerosolization of recombinant secretory leukoprotease inhibitor. Journal of Clinical Investigation. https://doi.org/10.1172/jci115994
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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