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Isolation and sequence of the cDNA for human protein S, a regulator of blood coagulation.
Open accessAbstract
Protein S is a cofactor of activated protein C; together they function as a regulator of blood coagulation. A human liver cDNA library constructed in bacteriophage lambda gt11 was screened with DNA fragments from a full-length bovine cDNA clone encoding protein S. Several cDNA clones were isolated and sequenced. The combined cDNA sequences encoded the mature protein and 15 residues of the leader sequence when compared to bovine protein S. Human protein S is a single-chain protein consisting of 635 amino acids with 82% homology to bovine protein S. After an NH2-terminal gamma-carboxyglutamic acid-containing region, there is a short region with thrombin-sensitive bond(s), followed by a region with four repeat sequences that are homologous to the precursor of mouse epidermal growth factor. In contrast to the other vitamin K-dependent plasma proteins, the COOH-terminal portion of human protein S does not show any resemblance to serine proteases.
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Citations
Cited by
The molecular basis of blood coagulation
Furie, B., & Furie, B. C. (1988) · Cell · doi:10.1016/0092-8674(88)90567-3 · Cited by 1,247
The Roles of Protein C and Thrombomodulin in the Regulation of Blood Coagulation
Esmon, C. T. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)83649-3 · Cited by 1,046
Manfioletti, G., Brancolini, C., Avanzi, G., & Schneider, C. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.8.4976 · Cited by 586
Varnum, B. C., Young, C., Elliott, G., Garcia, A., Bartley, T. D., Fridell, Y.-W., Hunt, R. W., Trail, G., Clogston, C., Toso, R. J., et al. (1995) · Nature · doi:10.1038/373623a0 · Cited by 481
Myers, K. V., Amend, S. R., & Pienta, K. J. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1022-2 · Cited by 470
Metadata
- Authors
- Lundwall, A., Dackowski, W., Cohen, E., Shaffer, M., Mahr, A., Dahlbäck, B., Stenflo, J., & Wydro, R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1986-09
- Volume
- 83
- Issue
- 18
- Pages
- 6716-6720
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1965376197
- Cited by
- 201
- References
- 0
- FWCI
- 7.60
- Type
- journal article
- Language
- en
- Open access
- green
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- Lundwall, A., Dackowski, W., Cohen, E., Shaffer, M., Mahr, A., Dahlbäck, B., Stenflo, J., & Wydro, R. (1986). Isolation and sequence of the cDNA for human protein S, a regulator of blood coagulation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.83.18.6716
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