The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade.
Open accessAbstract
A set of growth arrest-specific genes (gas) whose expression is negatively regulated after serum induction has previously been described (C. Schneider, R. M. King, and L. Philipson, Cell 54:787-793, 1988). The detailed analysis of one of them, gas6, is reported here, gas6 mRNA (2.6 kb) is abundantly expressed in serum-starved (48 h in 0.5% fetal calf serum) NIH 3T3 cells but decreases dramatically after fetal calf serum or basic fibroblast growth factor stimulation. The human homolog of gas6 was also cloned and sequenced, revealing a high degree of homology and a similar pattern of expression in IMR90 human fibroblasts. Computer analysis of the protein encoded by murine and human gas6 cDNAs showed significant homology (43 and 44% amino acid identity, respectively) to human protein S, a negative coregulator in the blood coagulation pathway. By using an anti-human Gas6 monospecific affinity-purified antibody, we show that the biosynthetic level of human Gas6 fully reflects mRNA expression in IMR90 human fibroblasts. This finding thus defines a new member of vitamin K-dependent proteins that is expressed in many human and mouse tissues and may be involved in the regulation of a protease cascade relevant in growth regulation.
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Metadata
- Authors
- Manfioletti, G., Brancolini, C., Avanzi, G., & Schneider, C.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1993-08
- Volume
- 13
- Issue
- 8
- Pages
- 4976-4985
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2165868580
- Cited by
- 586
- References
- 56
- FWCI
- 8.89
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade. https://app.cochat.ai/papers/10.1128/mcb.13.8.4976
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- Manfioletti, G., Brancolini, C., Avanzi, G., & Schneider, C. (1993). The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.13.8.4976
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