The DOI matches its Crossref record.
The avian beta-adrenergic receptor: primary structure and membrane topology.
Open accessAbstract
Partial amino acid sequence information allowed the isolation of cDNA clones encoding the turkey erythrocyte beta-adrenergic receptor. Antisera raised against synthetic peptides encoded by the cDNA crossreacted with the purified receptor and appropriate tryptic fragments, confirming the identity of the cDNA. The receptor is composed of 483 amino acids and has a molecular mass of 54 kDa. Its sequence suggests that it is arranged predominantly in seven membrane-spanning sequences and a long cytoplasmic carboxyl-terminal domain. The extracellular amino-terminal domain contains a consensus sequence for N-glycosylation. The beta-adrenergic receptor displays overall structural similarity and weak sequence homology with rhodopsin. Because both proteins act by regulating GTP-binding proteins, a compact structure based on seven membrane-spanning regions may be a general model for receptors that act on G proteins.
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Citations
Cited by
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Fent, K., Weston, A. A., & Caminada, D. (2006) · Aquatic Toxicology · doi:10.1016/j.aquatox.2005.09.009 · Cited by 3,223
Kobilka, B. K., Matsui, H., Kobilka, T. S., Yang-Feng, T. L., Francke, U., Caron, M. G., Lefkowitz, R. J., & Regan, J. W. (1987) · Science · doi:10.1126/science.2823383 · Cited by 787
A family of receptors coupled to guanine nucleotide regulatory proteins
Dohlman, H. G., Caron, M. G., & Lefkowitz, R. J. (1987) · Biochemistry · doi:10.1021/bi00384a001 · Cited by 631
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Morgan, P. J., Barrett, P., Howell, H. E., & Helliwell, R. (1994) · Neurochemistry International · doi:10.1016/0197-0186(94)90100-7 · Cited by 623
The dopamine D2 receptor: two molecular forms generated by alternative splicing.
Dal Toso, R., Sommer, B., Ewert, M., Herb, A., Pritchett, D. B., Bach, A., Shivers, B. D., & Seeburg, P. H. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb08585.x · Cited by 600
Metadata
- Authors
- Yarden, Y., Rodriguez, H., Wong, S. K., Brandt, D. R., May, D. C., Burnier, J., Harkins, R. N., Chen, E. Y., Ramachandran, J., & Ullrich, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1986-09
- Volume
- 83
- Issue
- 18
- Pages
- 6795-6799
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1971824802
- Cited by
- 248
- References
- 0
- FWCI
- 16.58
- Type
- journal article
- Language
- en
- Open access
- green
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- Yarden, Y., Rodriguez, H., Wong, S. K., Brandt, D. R., May, D. C., Burnier, J., Harkins, R. N., Chen, E. Y., Ramachandran, J., & Ullrich, A. (1986). The avian beta-adrenergic receptor: primary structure and membrane topology. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.83.18.6795
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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