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Cloning, Sequencing, and Expression of the Gene Coding for the Human Platelet α 2 -Adrenergic Receptor
Abstract
The gene for the human platelet α 2 -adrenergic receptor has been cloned with oligonucleotides corresponding to the partial amino acid sequence of the purified receptor. The identity of this gene has been confirmed by the binding of α 2 -adrenergic ligands to the cloned receptor expressed in Xenopus laevis oocytes. The deduced amino acid sequence is most similar to the recently cloned human β 2 - and β 1 -adrenergic receptors; however, similarities to the muscarinic cholinergic receptors are also evident. Two related genes have been identified by low stringency Southern blot analysis. These genes may represent additional α 2 -adrenergic receptor subtypes.
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Citations
Cited by
Arnsten, A. F. T. (1996) · Archives of General Psychiatry · doi:10.1001/archpsyc.1996.01830050084013 · Cited by 458
Historical review: A brief history and personal retrospective of seven-transmembrane receptors
Lefkowitz, R. J. (2004) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2004.06.006 · Cited by 417
Self-citationHorstman, D. A., Brandon, S., Wilson, A. L., Guyer, C. A., Cragoe, E. J., & Limbird, L. E. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45781-x · Cited by 271
Molecular genetics of human blue cone monochromacy
Nathans, J., Davenport, C. M., Maumenee, I. H., Lewis, R. A., Hejtmancik, J. F., Litt, M., Lovrien, E., Weleber, R., Bachynski, B., Zwas, F., et al. (1989) · Science · doi:10.1126/science.2788922 · Cited by 255
Structure, function, and regulation of adrenergic receptors
Strosberg, A. D. (1993) · Protein Science · doi:10.1002/pro.5560020802 · Cited by 248
Metadata
- Authors
- Kobilka, B. K., Matsui, H., Kobilka, T. S., Yang-Feng, T. L., Francke, U., Caron, M. G., Lefkowitz, R. J., & Regan, J. W.
- Venue
- Science
- Published
- 1987-10-30
- Volume
- 238
- Issue
- 4827
- Pages
- 650-656
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2006913937
- Cited by
- 787
- References
- 0
- FWCI
- 26.42
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kobilka, B. K., Matsui, H., Kobilka, T. S., Yang-Feng, T. L., Francke, U., Caron, M. G., Lefkowitz, R. J., & Regan, J. W. (1987). Cloning, Sequencing, and Expression of the Gene Coding for the Human Platelet α 2 -Adrenergic Receptor. Science. https://doi.org/10.1126/science.2823383
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
