The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Oxygen-dependent mutagenesis in Escherichia coli lacking superoxide dismutase.
Open accessAbstract
Escherichia coli double mutants (sodA sodB) completely lacking superoxide dismutase (SOD) have greatly enhanced mutation rates during aerobic growth. Single mutants lacking manganese SOD (MnSOD) but possessing iron SOD (FeSOD) have a smaller increase, and single mutants lacking FeSOD but possessing MnSOD do not show such an increase. The enhancement of mutagenesis is completely dependent on the presence of oxygen, and treatments that increase the flux of superoxide radicals produce even higher levels of mutagenesis. The presence of a plasmid overproducing either form of SOD reduces the level of mutagenesis to that of wild type, showing that the O2-dependent enhancement results from a lack of SOD. The enhancement of mutagenesis is RecA-independent, and a complete lack of SOD does not induce the SOS response during aerobic growth. However, the enhanced mutagenesis in aerobically grown sodA sodB mutants is largely dependent on functional exonuclease III, suggesting that the increased flux of superoxide radicals results in DNA lesions that can be acted on by this enzyme, leading to mutations.
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Citations
Cites
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Ames, B. N. (1983) · Science · doi:10.1126/science.6351251 · Cited by 2,969
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Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli
Witkin, E. M. (1976) · Bacteriological Reviews · doi:10.1128/br.40.4.869-907.1976 · Cited by 1,862
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The SOS regulatory system of Escherichia coli
Little, J. W., & Mount, D. W. (1982) · Cell · doi:10.1016/0092-8674(82)90085-x · Cited by 1,489
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Cited by
Rosen, D. R., Siddique, T., Patterson, D., Figlewicz, D. A., Sapp, P., Hentati, A., Donaldson, D., Goto, J., O'Regan, J. P., Deng, H.-X., et al. (1993) · Nature · doi:10.1038/362059a0 · Cited by 7,062
Antioxidant enzymes and human diseases
MatÉs, J. M., Pérez-Gómez, C., & De Castro, I. N. (1999) · Clinical Biochemistry · doi:10.1016/s0009-9120(99)00075-2 · Cited by 2,099
Cellular Defenses against Superoxide and Hydrogen Peroxide
Imlay, J. A. (2008) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.061606.161055 · Cited by 1,563
Superoxide Anion Radical (O·̄2), Superoxide Dismutases, and Related Matters
Fridovich, I. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.30.18515 · Cited by 1,337
Protection against oxygen radicals: an important defence mechanism studied in transgenic plants
FOYER, C. H., DESCOURVIÈRES, P., & KUNERT, K. J. (1994) · Plant, Cell & Environment · doi:10.1111/j.1365-3040.1994.tb00146.x · Cited by 1,245
Metadata
- Authors
- Farr, S. B., D'Ari, R., & Touati, D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1986-11
- Volume
- 83
- Issue
- 21
- Pages
- 8268-8272
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1995568065
- Cited by
- 307
- References
- 35
- FWCI
- 6.22
- Type
- journal article
- Language
- en
- Open access
- green
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- Farr, S. B., D'Ari, R., & Touati, D. (1986). Oxygen-dependent mutagenesis in Escherichia coli lacking superoxide dismutase. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.83.21.8268
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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