The DOI matches its Crossref record.
Purification of a factor from human placenta that stimulates capillary endothelial cell protease production, DNA synthesis, and migration.
Open accessAbstract
A protein that stimulates the production of plasminogen activator and latent collagenase in cultured bovine capillary endothelial cells has been purified 10(6)-fold from term human placenta by using a combination of heparin affinity chromatography, ion-exchange chromatography, and gel chromatography. The purified molecule has a molecular weight of 18,700 as determined by NaDodSO4/PAGE under both reducing and nonreducing conditions. The purified molecule stimulates the production of plasminogen activator and latent collagenase in a dose-dependent manner between 0.1 and 10 ng of protein/ml. The purified protein also stimulates DNA synthesis and chemotaxis in capillary endothelial cells in the same concentration range. Thus, this molecule has all of the properties predicted for an angiogenic factor.
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Cited by
Houck, K. A., Leung, D. W., Rowland, A. M., Winer, J., & Ferrara, N. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)35712-0 · Cited by 1,127
Saksela, O., Moscatelli, D., Sommer, A., & Rifkin, D. B. (1988) · The Journal of cell biology · doi:10.1083/jcb.107.2.743 · Cited by 804
Self-citationSaksela, O., & Rifkin, D. B. (1990) · The Journal of cell biology · doi:10.1083/jcb.110.3.767 · Cited by 539
Self-citationFlorkiewicz, R. Z., & Sommer, A. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.11.3978 · Cited by 522
Mignatti, P., Morimoto, T., & Rifkin, D. B. (1992) · Journal of Cellular Physiology · doi:10.1002/jcp.1041510113 · Cited by 451
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Metadata
- Authors
- Moscatelli, D., Presta, M., & Rifkin, D. B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1986-04
- Volume
- 83
- Issue
- 7
- Pages
- 2091-2095
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2049042095
- Cited by
- 347
- References
- 0
- FWCI
- 10.91
- Type
- journal article
- Language
- en
- Open access
- green
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- Moscatelli, D., Presta, M., & Rifkin, D. B. (1986). Purification of a factor from human placenta that stimulates capillary endothelial cell protease production, DNA synthesis, and migration. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.83.7.2091
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