The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Human basic fibroblast growth factor gene encodes four polypeptides: three initiate translation from non-AUG codons.
Open accessAbstract
Human basic fibroblast growth factor (bFGF) is an angiogenic polypeptide mitogen present in a wide variety of mesoderm- and neuroectoderm-derived tissues. bFGF cDNA and genomic clones predict a 17.8-kDa (155-amino acid) gene product based on the presence of a single putative translational initiator ATG codon. However, a bFGF protein isolated from human placenta contains two additional amino acids NH2-terminal to the predicted initiator methionine. We report here that the human cell line SK-HEP-1 coexpresses four molecular forms (17.8, 22.5, 23.1, and 24.2 kDa) of bFGF. The 17.8-kDa bFGF protein is translationally initiated at the previously predicted methionine (AUG) codon, whereas the 22.5-, 23.1-, and 24.2-kDa proteins initiate at unusual non-AUG codons. The higher molecular weight forms are colinear NH2-terminal extensions of the 18-kDa bFGF.
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Ribosomal initiation from an ACG codon in the Sendai virus P/C mRNA.
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Cited by
An analysis of vertebrate mRNA sequences: intimations of translational control.
Kozak, M. (1991) · The Journal of cell biology · doi:10.1083/jcb.115.4.887 · Cited by 1,635
Fibroblast growth factors, their receptors and signaling
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Angiogenesis: regulators and clinical applications
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Neuronal defects and delayed wound healing in mice lacking fibroblast growth factor 2
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Metadata
- Authors
- Florkiewicz, R. Z., & Sommer, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1989-06
- Volume
- 86
- Issue
- 11
- Pages
- 3978-3981
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1975749015
- Cited by
- 522
- References
- 15
- FWCI
- 13.02
- Type
- journal article
- Language
- en
- Open access
- green
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- Florkiewicz, R. Z., & Sommer, A. (1989). Human basic fibroblast growth factor gene encodes four polypeptides: three initiate translation from non-AUG codons. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.86.11.3978
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
