The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Expression of a multidrug-resistance gene in human tumors and tissues.
Open accessAbstract
The identification and cloning of a segment of a human multidrug resistance gene (mdr1) was reported recently. To examine the molecular basis of one type of multidrug resistance, we have prepared RNA from human tumors and normal tissues and measured their content of mdr1 RNA. We find that the mdr1 gene is expressed at a very high level in the adrenal gland; at a high level in the kidney; at intermediate levels in the lung, liver, lower jejunum, colon, and rectum; and at low levels in many other tissues. The mdr1 gene is also expressed in several human tumors, including many but not all tumors derived from the adrenal gland and the colon. In addition, increased expression was detected in a few tumors at the time of relapse following initial chemotherapy. Although controlled clinical studies will be required, our results suggest that measurement of mdr1 RNA may prove to be a valuable tool in the design of chemotherapy protocols.
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Self-citationTsuruo, T., Iida, H., Tsukagoshi, S., & Sakurai, Y. (1981) · PubMed · Cited by 1,459
Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines
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Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells.
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Self-citationHuman Multidrug-Resistant Cell Lines: Increased mdr 1 Expression Can Precede Gene Amplification
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Self-citationIsolation and genetic characterization of human KB cell lines resistant to multiple drugs
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Self-citationAltered surface membrane glycoproteins in Vinca alkaloid-resistant human leukemic lymphoblasts.
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Cited by
Multidrug resistance in cancer: role of ATP–dependent transporters
Gottesman, M. M., Fojo, T., & Bates, S. E. (2002) · Nature Reviews Cancer · doi:10.1038/nrc706 · Cited by 5,536
Self-citationThiebaut, F., Tsuruo, T., Hamada, H., Gottesman, M. M., Pastan, I., & Willingham, M. C. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.21.7735 · Cited by 2,777
Self-citationDrug resistance and combating drug resistance in cancer
Wang, X., Zhang, H., & Chen, X. (2019) · Cancer Drug Resistance · doi:10.20517/cdr.2019.10 · Cited by 1,085
Clinical Pharmacokinetics of Atorvastatin
Lennern??s, H. (2003) · Clinical Pharmacokinetics · doi:10.2165/00003088-200342130-00005 · Cited by 623
The molecular basis of multidrug resistance in cancer: The early years of P‐glycoprotein research
Gottesman, M. M., & Ling, V. (2006) · FEBS Letters · doi:10.1016/j.febslet.2005.12.060 · Cited by 558
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Metadata
- Authors
- Fojo, A. T., Ueda, K., Slamon, D. J., Poplack, D. G., Gottesman, M. M., & Pastan, I.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1987-01
- Volume
- 84
- Issue
- 1
- Pages
- 265-269
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2037621239
- Cited by
- 1,544
- References
- 21
- FWCI
- 32.84
- Type
- journal article
- Language
- en
- Open access
- green
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- Fojo, A. T., Ueda, K., Slamon, D. J., Poplack, D. G., Gottesman, M. M., & Pastan, I. (1987). Expression of a multidrug-resistance gene in human tumors and tissues. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.84.1.265
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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