The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Parathyroid hormone-related protein purified from a human lung cancer cell line.
Open accessAbstract
A protein with biological activities similar to parathyroid hormone (PTH) has been purified from serum-free culture medium obtained from a human lung cancer cell line (BEN). A major protein band of 18 kDa was obtained on NaDodSO4/polyacrylamide gels, with faint bands at 35 kDa and 67 kDa. Biological activity was associated only with the 18-kDa band. Amino acid sequence analysis of the material purified by HPLC revealed that 8 of the 16 residues were identical with those of human PTH. Antibody raised to a corresponding synthetic peptide recognized the PTH-related material but showed less than 1% cross-reactivity with human PTH amino-terminal peptides. BEN cells contained PTH DNA, but not PTH messenger RNA, indicating involvement of another gene. The purified PTH-related protein had a specific biological activity approximately equal to 6 times greater than that of bovine PTH(1-34). The PTH-related protein may have a role in the syndrome of humoral hypercalcemia of malignancy.
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Cites
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Cited by
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Metadata
- Authors
- Moseley, J. M., Kubota, M., Diefenbach-Jagger, H., Wettenhall, R. E., Kemp, B. E., Suva, L. J., Rodda, C. P., Ebeling, P. R., Hudson, P. J., & Zajac, J. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1987-07
- Volume
- 84
- Issue
- 14
- Pages
- 5048-5052
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2034419606
- Cited by
- 734
- References
- 17
- FWCI
- 54.91
- Type
- journal article
- Language
- en
- Open access
- green
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- Moseley, J. M., Kubota, M., Diefenbach-Jagger, H., Wettenhall, R. E., Kemp, B. E., Suva, L. J., Rodda, C. P., Ebeling, P. R., Hudson, P. J., & Zajac, J. D. (1987). Parathyroid hormone-related protein purified from a human lung cancer cell line. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.84.14.5048
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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