The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Factors associated with humoral hypercalcemia of malignancy stimulate adenylate cyclase in osteoblastic cells.
Open accessAbstract
The culture media of three cell lines, a human prostate carcinoma (PC3), a rat Leydig cell tumor (Rice-500), and a rat carcinosarcoma (WRC-256), that were derived from tumors associated with humoral hypercalcemia of malignancy (HHM), were examined for stimulation of adenylate cyclase in ROS 17/2.8 osteoblastic cells and for bone resorptive activity in culture. Cells from a nonhypercalcemic variant of the WRC256 tumor served as control. Extracts from three solid human tumors, a lung adenocarcinoma from a patient with HHM and two adenocarcinoma from normocalcemic patients (lung and colon), were also examined for adenylate cyclase stimulation. We found excellent correlation between stimulation of cyclic AMP accumulation in ROS 17/2.8 cells and bone resorbing activity in culture, or production of HHM in vivo. Stimulation of adenylate cyclase by HHM factors was inhibited by the parathyroid hormone competitive inhibitor, [8norleucyl, 18norleucyl, 34tyrosinyl] bovine parathyroid hormone (3-34) amide.
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Citations
Cites
Role of osteoblasts in hormonal control of bone resorption—A hypothesis
Rodan, G. A., & Martin, T. J. (1981) · Calcified Tissue International · doi:10.1007/bf02409454 · Cited by 982
Self-citation
Cited by
Parathyroid hormone-related protein purified from a human lung cancer cell line.
Moseley, J. M., Kubota, M., Diefenbach-Jagger, H., Wettenhall, R. E., Kemp, B. E., Suva, L. J., Rodda, C. P., Ebeling, P. R., Hudson, P. J., & Zajac, J. D. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.14.5048 · Cited by 734
Chorev, M., Roubini, E., McKee, R. L., Gibbons, S. W., Goldman, M. E., Caulfield, M. P., & Rosenblatt, M. (1991) · Biochemistry · doi:10.1021/bi00238a022 · Cited by 107
Michelangeli, V. P., Findlay, D. M., Fletcher, A., & Martin, T. J. (1986) · Calcified Tissue International · doi:10.1007/bf02555739 · Cited by 49
Ingle (1991) · doi:10.1002/1097-0142(19910215)67:4
Metadata
- Authors
- Rodan, S. B., Insogna, K. L., Vignery, A. M., Stewart, A. F., Broadus, A. E., D'Souza, S. M., Bertolini, D. R., Mundy, G. R., & Rodan, G. A.
- Venue
- Journal of Clinical Investigation
- Published
- 1983-10-01
- Volume
- 72
- Issue
- 4
- Pages
- 1511-1515
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2059511515
- Cited by
- 221
- References
- 1
- FWCI
- 6.90
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Factors associated with humoral hypercalcemia of malignancy stimulate adenylate cyclase in osteoblastic cells. https://app.cochat.ai/papers/10.1172/jci111108
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- Rodan, S. B., Insogna, K. L., Vignery, A. M., Stewart, A. F., Broadus, A. E., D'Souza, S. M., Bertolini, D. R., Mundy, G. R., & Rodan, G. A. (1983). Factors associated with humoral hypercalcemia of malignancy stimulate adenylate cyclase in osteoblastic cells. Journal of Clinical Investigation. https://doi.org/10.1172/jci111108
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
