The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Cofilin is a component of intranuclear and cytoplasmic actin rods induced in cultured cells.
Open accessAbstract
Incubation of cultured cells under specific conditions induces a dramatic change in the actin organization: induction of intranuclear and/or cytoplasmic actin rods (actin paracrystal-like intracellular structures). We have found that cofilin, a 21-kDa actin-binding protein, is a component of these rods. Antibodies directed against cofilin labeled intranuclear actin rods induced in cells treated with dimethyl sulfoxide or exposed to heat shock and also labeled cytoplasmic actin rods induced in cells incubated in specific salt buffers. Moreover, we found that these actin rods are not stained with fluorescent phalloidin derivatives at all and appear to be right-handed helices, different from straight bundles of F-actin such as stress fibers. In vitro experiments revealed that cofilin and phalloidin compete with each other for binding to F-actin. Since cofilin and phalloidin have the ability to stoichiometrically bind actin molecule in the filament in vitro, the above results seem to suggest that cofilin directly binds to actin molecule in nearly an equimolar ratio in these rods. We call these rods "actin/cofilin rods."
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Raza, H., John, A., & Nemmar, A. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350087 · Cited by 47,221
The Regulation of Rabbit Skeletal Muscle Contraction
Spudich, J. A., & Watt, S. (1971) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)62016-2 · Cited by 4,493
Fluorescent phallotoxin, a tool for the visualization of cellular actin.
Wulf, E., Deboben, A., Bautz, F. A., Faulstich, H., & Wieland, T. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.9.4498 · Cited by 786
Actin polymerization and its regulation by proteins from nonmuscle cells.
Korn, E. D. (1982) · Physiological Reviews · doi:10.1152/physrev.1982.62.2.672 · Cited by 739
Nonmuscle Actin-Binding Proteins
Stossel, T. P., Chaponnier, C., Ezzell, R. M., Hartwig, J. H., Janmey, P. A., Kwiatkowski, D. J., Lind, S. E., Smith, D. B., Southwick, F. S., Yin, H. L., et al. (1985) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.01.110185.002033 · Cited by 576
Actin-binding proteins—regulators of cell architecture and motility
Weeds, A. (1982) · Nature · doi:10.1038/296811a0 · Cited by 467
Barak, L. S., Yocum, R. R., Nothnagel, E. A., & Webb, W. W. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.2.980 · Cited by 438
Welch, W. J., & Suhan, J. P. (1985) · The Journal of cell biology · doi:10.1083/jcb.101.4.1198 · Cited by 427
Yahara, I., Harada, F., Sekita, S., Yoshihira, K., & Natori, S. (1982) · The Journal of Cell Biology · doi:10.1083/jcb.92.1.69 · Cited by 321
Self-citation
Cited by
Actin dynamics and cofilin‐actin rods in alzheimer disease
Bamburg, J. R., & Bernstein, B. W. (2016) · Cytoskeleton · doi:10.1002/cm.21282 · Cited by 181
ADF/Cofilin-Actin Rods in Neurodegenerative Diseases
Bamburg, J. R., Bernstein, B. W., Davis, R. C., Flynn, K. C., Goldsbury, C., Jensen, J. R., Maloney, M. T., Marsden, I. T., Minamide, L. S., Pak, C. W., et al. (2010) · Current Alzheimer Research · doi:10.2174/156720510791050902 · Cited by 173
Munsie, L., Caron, N., Atwal, R. S., Marsden, I., Wild, E. J., Bamburg, J. R., Tabrizi, S. J., & Truant, R. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr075 · Cited by 133
Cichon, J., Sun, C., Chen, B., Jiang, M., Chen, X. A., Sun, Y., Wang, Y., & Chen, G. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.301911 · Cited by 95
CryoET shows cofilactin filaments inside the microtubule lumen
Ventura Santos, C., Rogers, S. L., & Carter, A. P. (2023) · The EMBO Reports · doi:10.15252/embr.202357264 · Cited by 11
Metadata
- Authors
- Nishida, E., Iida, K., Yonezawa, N., Koyasu, S., Yahara, I., & Sakai, H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1987-08
- Volume
- 84
- Issue
- 15
- Pages
- 5262-5266
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1976493941
- Cited by
- 275
- References
- 26
- FWCI
- 1.98
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Cofilin is a component of intranuclear and cytoplasmic actin rods induced in cultured cells. https://app.cochat.ai/papers/10.1073/pnas.84.15.5262
- The paper
- Nishida, E., Iida, K., Yonezawa, N., Koyasu, S., Yahara, I., & Sakai, H. (1987). Cofilin is a component of intranuclear and cytoplasmic actin rods induced in cultured cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.84.15.5262
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
