The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Inhibitory action of transforming growth factor beta on endothelial cells.
Open accessAbstract
In the present study, we show that transforming growth factor beta (TGF-beta) strongly inhibits fibroblast growth factor-induced proliferation and motility of bovine endothelial cells in tissue culture. TGF-beta also prevents the phorbol ester-induced invasion of capillary endothelial cells into collagen matrices--i.e., blocks angiogenesis in vitro. TGF-beta promotes the incorporation of fibronectin into the extracellular matrix of endothelial cells and stimulates the secretion of other proteins--mainly of 55- and 180-kDa components. We show furthermore that endothelial cells express TGF-beta receptors similar in size to those of other tissue culture cell lines: a 280-kDa complex is present in subconfluent cells, and 85- and 72-kDa protein bands are seen in confluent cells. The various effects of TGF-beta on endothelial cells suggest that these cells are an important target of TGF-beta during wound healing and angiogenesis.
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Cites
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Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors
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Defective haematopoiesis and vasculogenesis in transforming growth factor-β1 knock out mice
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Metadata
- Authors
- Müller, G., Behrens, J., Nussbaumer, U., Böhlen, P., & Birchmeier, W.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1987-08
- Volume
- 84
- Issue
- 16
- Pages
- 5600-5604
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2035819392
- Cited by
- 323
- References
- 44
- FWCI
- 7.27
- Type
- journal article
- Language
- en
- Open access
- green
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- Müller, G., Behrens, J., Nussbaumer, U., Böhlen, P., & Birchmeier, W. (1987). Inhibitory action of transforming growth factor beta on endothelial cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.84.16.5600
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
