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Cited by 1,272

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Transforming growth factor type beta induces monocyte chemotaxis and growth factor production.

Open access
Wahl, S M, Hunt, D A, Wakefield, L M, McCartney-Francis, N, Wahl, L M, Roberts, A B, Sporn, M B·1987·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.84.16.5788
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Abstract

Recent studies have focused on the potential role of transforming growth factor type beta (TGF-beta) as an immunoregulatory peptide. In this context, we demonstrate that TGF-beta is a potent chemoattractant for human peripheral blood monocytes. At concentrations from 0.1 to 10 pg/ml, TGF-beta induces directed monocyte migration in vitro. Consistent with this observation is the expression of high-affinity TGF-beta receptors on the monocytes with a Kd of 1-10 pM. At higher concentrations of TGF-beta (greater than or equal to 1 ng/ml), monocytes are stimulated to generate biologically active mediator(s) that enhance fibroblast growth. Gene expression for one of these growth factors, interleukin 1, is induced in monocytes within hours after exposure to TGF-beta. Thus, TGF-beta may provide an important signal for monocyte recruitment and for regulation of their synthesis of mediators of fibroblast growth and activity in wound healing.

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Crossref · 10.1073/pnas.84.16.5788

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Metadata

Authors
Wahl, S. M., Hunt, D. A., Wakefield, L. M., McCartney-Francis, N., Wahl, L. M., Roberts, A. B., & Sporn, M. B.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
1987-08
Volume
84
Issue
16
Pages
5788-5792
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.84.16.5788
OpenAlex
W2062199188
Cited by
1,272
References
1
FWCI
20.74
Type
journal article
Language
en
Open access
green

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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