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Antioxidant activity of albumin-bound bilirubin.
Open accessAbstract
Bilirubin, when bound to human albumin and at concentrations present in normal human plasma, protects albumin-bound linoleic acid from peroxyl radical-induced oxidation in vitro. Initially, albumin-bound bilirubin (Alb-BR) is oxidized at the same rate as peroxyl radicals are formed and biliverdin is produced stoichiometrically as the oxidation product. On an equimolar basis, Alb-BR successfully competes with uric acid for peroxyl radicals but is less efficient in scavenging these radicals than vitamin C. These results show that 1 mol of Alb-BR can scavenge 2 mol of peroxyl radicals and that small amounts of plasma bilirubin are sufficient to prevent oxidation of albumin-bound fatty acids as well as of the protein itself. The data indicate a role for Alb-BR as a physiological antioxidant in plasma and the extravascular space.
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Citations
Cited by
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Powers, S. K., & Jackson, M. J. (2008) · Physiological Reviews · doi:10.1152/physrev.00031.2007 · Cited by 2,459
Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency
Yachie, A., Niida, Y., Wada, T., Igarashi, N., Kaneda, H., Toma, T., Ohta, K., Kasahara, Y., & Koizumi, S. (1999) · Journal of Clinical Investigation · doi:10.1172/jci4165 · Cited by 1,255
Antioxidant defenses and lipid peroxidation in human blood plasma.
Frei, B., Stocker, R., & Ames, B. N. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.24.9748 · Cited by 1,252
Self-citationChoi, A. M., & Alam, J. (1996) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.15.1.8679227 · Cited by 1,126
Lee, P. J., Jiang, B.-H., Chin, B. Y., Iyer, N. V., Alam, J., Semenza, G. L., & Choi, A. K. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.9.5375 · Cited by 782
Metadata
- Authors
- Stocker, R., Glazer, A. N., & Ames, B. N.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1987-08
- Volume
- 84
- Issue
- 16
- Pages
- 5918-5922
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2093057466
- Cited by
- 766
- References
- 0
- FWCI
- 17.31
- Type
- journal article
- Language
- en
- Open access
- green
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- Stocker, R., Glazer, A. N., & Ames, B. N. (1987). Antioxidant activity of albumin-bound bilirubin. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.84.16.5918
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