The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Human endothelial cells synthesize and express an Arg-Gly-Asp-directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor.
Open accessAbstract
Human umbilical vein endothelial cells express a heterodimeric adhesion receptor complex consisting of noncovalently associated alpha and beta subunits that under reducing conditions have molecular masses of 135 kDa and 115 kDa, respectively. This complex can be isolated in pure form from an affinity matrix consisting of an Arg-Gly-Asp-containing heptapeptide and is specifically immunoprecipitated with monoclonal antibodies (mAbs) directed against the vitronectin receptor of human melanoma cells. These data suggest that this complex is one member of a large family of cell adhesion receptors. One of the mAbs, LM609, inhibits the attachment of human endothelial cells to fibrinogen, von Willebrand factor, and vitronectin yet has no effect on the attachment of these cells to fibronectin, collagen, or laminin. In addition, mAb LM609 inhibits attachment of endothelial cells to an immobilized synthetic peptide containing the Arg-Gly-Asp sequence. This adhesion receptor appears structurally similar to the IIb/IIIa glycoprotein complex expressed on platelets yet is antigenically distinct, since mAb LM609 fails to recognize IIb/IIIa glycoproteins. This receptor organizes in clusters on endothelial cells during their attachment to von Willebrand factor, vitronectin, or the Arg-Gly-Asp-containing heptapeptide. The data presented in this report suggest that Arg-Gly-Asp recognition may play a significant role in biological events associated with vascular proliferation.
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Cites
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Raza, H., John, A., & Nemmar, A. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350087 · Cited by 47,221
Jaffe, E. A., Nachman, R. L., Becker, C. G., & Minick, C. R. (1973) · Journal of Clinical Investigation · doi:10.1172/jci107470 · Cited by 6,856
Integrins: A family of cell surface receptors
HYNES, R. (1987) · Cell · doi:10.1016/0092-8674(87)90233-9 · Cited by 4,249
Arg-Gly-Asp: A versatile cell recognition signal
Ruoslahti, E., & Pierschbacher, M. D. (1986) · Cell · doi:10.1016/0092-8674(86)90259-x · Cited by 1,397
Pytela, R., Pierschbacher, M. D., & Ruoslahti, E. (1985) · Cell · doi:10.1016/0092-8674(85)90322-8 · Cited by 1,101
Pytela, R., Pierschbacher, M. D., Ginsberg, M. H., Plow, E. F., & Ruoslahti, E. (1986) · Science · doi:10.1126/science.2420006 · Cited by 925
Plow, E. F., Pierschbacher, M. D., Ruoslahti, E., Marguerie, G. A., & Ginsberg, M. H. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.23.8057 · Cited by 581
Horwitz, A., Duggan, K., Greggs, R., Decker, C., & Buck, C. (1985) · The Journal of cell biology · doi:10.1083/jcb.101.6.2134 · Cited by 501
Fitzgerald, L. A., Steiner, B., Rall, S. C., Lo, S. S., & Phillips, D. R. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61290-6 · Cited by 455
Cited by
Requirement of Vascular Integrin α v β 3 for Angiogenesis
Brooks, P. C., Clark, R. A. F., & Cheresh, D. A. (1994) · Science · doi:10.1126/science.7512751 · Cited by 3,020
Self-citationIntegrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels
Brooks, P. C., Montgomery, A. M. P., Rosenfeld, M., Reisfeld, R. A., Hu, T., Klier, G., & Cheresh, D. A. (1994) · Cell · doi:10.1016/0092-8674(94)90007-8 · Cited by 2,262
Self-citationFocal Adhesions: Transmembrane Junctions Between the Extracellular Matrix and the Cytoskeleton
Burridge, K., Fath, K., Kelly, T., Nuckolls, G., & Turner, C. (1988) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.04.110188.002415 · Cited by 2,120
Fibrinogen and fibrin structure and functions
MOSESSON, M. W. (2005) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2005.01365.x · Cited by 1,695
Tonnesen, M. G., Feng, X., & Clark, R. A. F. (2000) · Journal of Investigative Dermatology Symposium Proceedings · doi:10.1046/j.1087-0024.2000.00014.x · Cited by 1,463
Metadata
- Authors
- Cheresh, D. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1987-09
- Volume
- 84
- Issue
- 18
- Pages
- 6471-6475
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2044806537
- Cited by
- 561
- References
- 21
- FWCI
- 8.52
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Human endothelial cells synthesize and express an Arg-Gly-Asp-directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor. https://app.cochat.ai/papers/10.1073/pnas.84.18.6471
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- Cheresh, D. A. (1987). Human endothelial cells synthesize and express an Arg-Gly-Asp-directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.84.18.6471
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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