The DOI matches its Crossref record; 95 of the 95 references it cites were found in a registry or an index.
Focal Adhesions: Transmembrane Junctions Between the Extracellular Matrix and the Cytoskeleton
Open accessAbstract
Many cells grown in tissue culture adhere tightly to the underlying substrate through discrete regions of the plasma membrane, referred to as adhesion plaques, focal contacts, or focal adhesions. In these regions where the surface of the cell comes closest to the substrate, the plasma membrane is specialized at its cytoplasmic face for anchoring stress fibers, the large bundles of microfilaments that are prominent in many cultured cells. In this review we discuss the composition and organization of focal adhesions. Many of their characteristics indicate that they are structurally and functionally equivalent to the adhesions made by many cells to the extracellular matrix (ECM) in vivo. We also consider the regulatory proteins that have been identified in focal adhesions since these regions are interesting not only as models for studying the links between the extracellular matrix and the cytoskeleton, but also as sites of transmembrane communication between the extracellular environment and the cytoplasm. Many features of focal adhesions, some of which are not considered here, have been reviewed previously (Burridge 1986; Woods and Couchman 1988).
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Cites
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Cited by
Adhesion receptors of the immune system
Springer, T. A. (1990) · Nature · doi:10.1038/346425a0 · Cited by 6,477
Cell Migration: A Physically Integrated Molecular Process
Lauffenburger, D. A., & Horwitz, A. F. (1996) · Cell · doi:10.1016/s0092-8674(00)81280-5 · Cited by 3,915
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Davies, P. F. (1995) · Physiological Reviews · doi:10.1152/physrev.1995.75.3.519 · Cited by 2,802
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Baker, B. M., & Chen, C. S. (2012) · Journal of Cell Science · doi:10.1242/jcs.079509 · Cited by 1,760
Signal transduction from the extracellular matrix.
Juliano, R. L., & Haskill, S. (1993) · The Journal of cell biology · doi:10.1083/jcb.120.3.577 · Cited by 1,683
Metadata
- Authors
- Burridge, K., Fath, K., Kelly, T., Nuckolls, G., & Turner, C.
- Venue
- Annual Review of Cell Biology
- Publisher
- Annual Reviews
- Published
- 1988-11
- Volume
- 4
- Issue
- 1
- Pages
- 487-525
- ISSN
- 0743-4634 (ISSN-L)
- OpenAlex
- W2112093320
- Cited by
- 2,120
- References
- 95
- FWCI
- 28.92
- Type
- journal article
- Language
- en
- Open access
- green
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- Burridge, K., Fath, K., Kelly, T., Nuckolls, G., & Turner, C. (1988). Focal Adhesions: Transmembrane Junctions Between the Extracellular Matrix and the Cytoskeleton. Annual Review of Cell Biology. https://doi.org/10.1146/annurev.cb.04.110188.002415
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
