The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Human immunodeficiency virus long terminal repeat responds to T-cell activation signals.
Open accessAbstract
Human immunodeficiency virus (HIV), the causative agent of AIDS, infects and kills lymphoid cells bearing the CD4 antigen. In an infected cell, a number of cellular as well as HIV-encoded gene products determine the levels of viral gene expression and HIV replication. Efficient HIV-replication occurs in activated T cells. Utilizing transient expression assays, we show that gene expression directed by the HIV long terminal repeat (LTR) increases in response to T-cell activation signals. The effects of T-cell activation and of the HIV-encoded trans-activator (TAT) are multiplicative. Analysis of mutations and deletions in the HIV LTR reveals that the region responding to T-cell activation signals is located at positions -105 to -80. These sequences are composed of two direct repeats, which are homologous to the core transcriptional enhancer elements in the simian virus 40 genome. Our studies reveal that these elements function as the HIV enhancer. By acting directly on the HIV LTR, T-cell activation may play an important role in HIV gene expression and in the activation of latent HIV.
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Cites
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Cited by
In vivo fate of HIV-1-infected T cells: Quantitative analysis of the transition to stable latency
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HIV-1 Tat protein increases transcriptional initiation and stabilizes elongation
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HIV-1/ Mycobacterium tuberculosis Coinfection Immunology: How Does HIV-1 Exacerbate Tuberculosis?
Diedrich, C. R., & Flynn, J. L. (2011) · Infection and Immunity · doi:10.1128/iai.01126-10 · Cited by 266
Expression profile of host restriction factors in HIV-1 elite controllers
Abdel-Mohsen, M., Raposo, R. A. S., Deng, X., Li, M., Liegler, T., Sinclair, E., Salama, M. S., Ghanem, H. E.-D. A., Hoh, R., Wong, J. K., et al. (2013) · Retrovirology · doi:10.1186/1742-4690-10-106 · Cited by 96
Metadata
- Authors
- Tong-Starksen, S. E., Luciw, P. A., & Peterlin, B. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1987-10
- Volume
- 84
- Issue
- 19
- Pages
- 6845-6849
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1977660540
- Cited by
- 271
- References
- 38
- FWCI
- 7.83
- Type
- journal article
- Language
- en
- Open access
- green
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