The DOI matches its Crossref record; 86 of the 86 references it cites were found in a registry or an index.
HIV-1/ Mycobacterium tuberculosis Coinfection Immunology: How Does HIV-1 Exacerbate Tuberculosis?
Open accessAbstract
Human immunodeficiency virus type 1 (HIV) and Mycobacterium tuberculosis have become intertwined over the past few decades in a “syndemic” that exacerbates the morbidity and mortality associated with each pathogen alone. The severity of the coinfection has been extensively examined in clinical studies. The extrapolation of peripheral evidence from clinical studies has increased our basic understanding of how HIV increases susceptibility to TB. These studies have resulted in multiple hypotheses of how HIV exacerbates TB pathology through the manipulation of granulomas. Granulomas can be located in many tissues, most prominently the lungs and associated lymph nodes, and are made up of multiple immune cells that can actively contain M. tuberculosis . Granuloma-based research involving both animal models and clinical studies is needed to confirm these hypotheses, which will further our understanding of this coinfection and may lead to better treatment options. This review examines the data that support each hypothesis of how HIV manipulates TB pathology while emphasizing a need for more tissue-based experiments.
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Cited by
Syndemics and the biosocial conception of health
Singer, M., Bulled, N., Ostrach, B., & Mendenhall, E. (2017) · The Lancet · doi:10.1016/s0140-6736(17)30003-x · Cited by 1,491
Metadata
- Authors
- Diedrich, C. R., & Flynn, J. L.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 2011-04
- Volume
- 79
- Issue
- 4
- Pages
- 1407-1417
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W2168051914
- Cited by
- 266
- References
- 86
- FWCI
- 13.21
- Type
- journal article
- Language
- en
- Open access
- green
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- Diedrich, C. R., & Flynn, J. L. (2011). HIV-1/ Mycobacterium tuberculosis Coinfection Immunology: How Does HIV-1 Exacerbate Tuberculosis? Infection and Immunity. https://doi.org/10.1128/iai.01126-10
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
