The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Neurosteroids: oligodendrocyte mitochondria convert cholesterol to pregnenolone.
Open accessAbstract
Oligodendrocyte mitochondria from 21-day-old Sprague-Dawley male rats were incubated with 100 nM [3H]cholesterol. It yielded [3H]pregnenolone at a rate of 2.5 +/- 0.7 and 5-[3H]pregnene-3 beta, 20 alpha-diol at a rate of 2.5 +/- 1.1 pmol per mg of protein per hr. Cultures of glial cells from 19- to 21-day-old fetuses (a mixed population of astrocytes and oligodendrocytes) were incubated for 24 hr with [3H]mevalonolactone. [3H]Cholesterol, [3H]pregnenolone, and 5-[3H]pregnene-3 beta, 20 alpha-diol were characterized in cellular extracts. The formation of the 3H-labeled steroids was increased by dibutyryl cAMP (0.2 mM) added to the culture medium. The active cholesterol side-chain cleavage mechanism, recently suggested immunohistochemically and already observed in cultures of C6 glioma cells, reinforces the concept of "neurosteroids" applied to delta 5-3 beta-hydroxysteroids previously isolated from brain.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Pregnenolone and its sulfate ester in the rat brain
Corpéchot, C., Synguelakis, M., Talha, S., Axelson, M., Sjövall, J., Vihko, R., Baulieu, E.-E., & Robel, P. (1983) · Brain Research · doi:10.1016/0006-8993(83)90797-7 · Cited by 385
Self-citationBROWN, M. S., KOVANEN, P. T., & GOLDSTEIN, J. L. (1979) · Proceedings of the 1978 Laurentian Hormone Conference · doi:10.1016/b978-0-12-571135-7.50009-6 · Cited by 311
Cited by
Multiple Actions of Steroid Hormones—A Focus on Rapid, Nongenomic Effects
Falkenstein, E., Tillmann, H.-C., Christ, M., Feuring, M., & Wehling, M. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01468-6 · Cited by 991
Purdy, R. H., Morrow, A. L., Moore, P. H., & Paul, S. M. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.10.4553 · Cited by 951
Neurosteroids: biosynthesis and function of these novel neuromodulators
Compagnone, N. A., & Mellon, S. H. (2000) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1999.0188 · Cited by 820
NEUROSTEROIDS: A NOVEL FUNCTION OF THE BRAIN
Baulieu, E. E. (1998) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(98)00071-7 · Cited by 622
Self-citationNeurosteroid metabolism in the human brain
Stoffel-Wagner, B. (2001) · European Journal of Endocrinology · doi:10.1530/eje.0.1450669 · Cited by 538
Metadata
- Authors
- Hu, Z. Y., Bourreau, E., Jung-Testas, I., Robel, P., & Baulieu, E. E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1987-12
- Volume
- 84
- Issue
- 23
- Pages
- 8215-8219
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1992357100
- Cited by
- 293
- References
- 2
- FWCI
- 2.77
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Neurosteroids: oligodendrocyte mitochondria convert cholesterol to pregnenolone. https://app.cochat.ai/papers/10.1073/pnas.84.23.8215
- The paper
- Hu, Z. Y., Bourreau, E., Jung-Testas, I., Robel, P., & Baulieu, E. E. (1987). Neurosteroids: oligodendrocyte mitochondria convert cholesterol to pregnenolone. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.84.23.8215
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
