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cDNA sequence, protein structure, and chromosomal location of the human gene for poly(ADP-ribose) polymerase.
Open accessAbstract
Recently we described a full-length cDNA for the human nuclear enzyme poly(ADP-ribose) polymerase. Here, we report the chromosomal localization and partial map of the human gene for this enzyme as well as the complete coding sequence for this protein. The nucleotide sequence reveals a single 3042-base open reading frame encoding a protein with a predicted Mr of 113,135. A comparison of this deduced amino acid sequence with the amino acid sequence of three peptides derived from human poly(ADP-ribose) polymerase revealed a match of 27 amino acid residues. A computer-derived structural analysis of the enzyme and a search for similarities with other proteins confirmed that the polymerase belongs to a subfamily of DNA/NAD-binding proteins and DNA-repair proteins. Possible Zn2+-binding "fingers," a nucleotide-binding fold, and a nuclear transport signal were noted. Additionally, chromosomal mapping has identified polymerase-hybridizing sequences on human chromosomes 1 (the active gene), 13, and 14 (processed pseudogenes). Using the polymerase cDNA as a probe, we also have detected several DNA restriction fragment length polymorphisms in normal humans.
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Citations
Cited by
Antinuclear Antibodies: Diagnostic Markers for Autoimmune Diseases and Probes for Cell Biology
Tan, E. M. (1989) · Advances in Immunology · doi:10.1016/s0065-2776(08)60641-0 · Cited by 1,514
PARP-2, A Novel Mammalian DNA Damage-dependent Poly(ADP-ribose) Polymerase
Amé, J.-C., Rolli, V., Schreiber, V., Niedergang, C., Apiou, F., Decker, P., Muller, S., Höger, T., Murcia, J. M.-D., & de Murcia, G. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.25.17860 · Cited by 745
Hassa, P. (2008) · Frontiers in Bioscience · doi:10.2741/2909 · Cited by 584
Lai, J. S., & Herr, W. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.15.6958 · Cited by 448
PARP-1, a determinant of cell survival in response to DNA damage
Bouchard, V. J., Rouleau, M., & Poirier, G. G. (2003) · Experimental Hematology · doi:10.1016/s0301-472x(03)00083-3 · Cited by 388
Metadata
- Authors
- Cherney, B. W., McBride, O. W., Chen, D. F., Alkhatib, H., Bhatia, K., Hensley, P., & Smulson, M. E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1987-12
- Volume
- 84
- Issue
- 23
- Pages
- 8370-8374
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1985598285
- Cited by
- 180
- References
- 0
- FWCI
- 3.04
- Type
- journal article
- Language
- en
- Open access
- green
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- Cherney, B. W., McBride, O. W., Chen, D. F., Alkhatib, H., Bhatia, K., Hensley, P., & Smulson, M. E. (1987). cDNA sequence, protein structure, and chromosomal location of the human gene for poly(ADP-ribose) polymerase. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.84.23.8370
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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