The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Reactive free radical generation in vivo in heart and liver of ethanol-fed rats: correlation with radical formation in vitro.
Open accessAbstract
Rats fed a high-fat ethanol-containing diet for 2 weeks were found to generate free radicals in liver and heart in vivo. The radicals are believed to be carbon-centered radicals, were detected by administering spin-trapping agents to the rats, and were characterized by electron paramagnetic resonance spectroscopy. The radicals in the liver were demonstrated to be localized in the endoplasmic reticulum. Rats fed ethanol in a low-fat diet showed significantly less free radical generation. Control animals given isocaloric diets without ethanol showed no evidence of free radicals in liver and heart. When liver microsomes prepared from rats fed the high-fat ethanol diet were incubated in a system containing ethanol, NADPH, and a spin-trapping agent, the generation of 1-hydroxyethyl radicals was observed. The latter was verified by using 13C-substituted ethanol. Microsomes from animals fed the high-fat ethanol-containing diet had higher levels of cytochrome P-450 than microsomes from rats fed the low-fat ethanol-containing diet. The results suggest that the consumption of ethanol results in the production of free radicals in rat liver and heart in vivo that appear to initiate lipid peroxidation.
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Citations
Cites
The Carbon Monoxide-binding Pigment of Liver Microsomes
Omura, T., & Sato, R. (1964) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)82244-3 · Cited by 11,781
Cited by
CYP2E1 and oxidative liver injury by alcohol
Lu, Y., & Cederbaum, A. I. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.11.004 · Cited by 805
Bolli, R., Patel, B. S., Jeroudi, M. O., Lai, E. K., & McCay, P. B. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113621 · Cited by 687
Self-citationBolli, R., Jeroudi, M. O., Patel, B. S., Aruoma, O. I., Halliwell, B., Lai, E. K., & McCay, P. B. (1989) · Circulation Research · doi:10.1161/01.res.65.3.607 · Cited by 579
Self-citationYou, M., Fischer, M., Deeg, M. A., & Crabb, D. W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202411200 · Cited by 543
Ekström, G., & Ingelman-Sundberg, M. (1989) · Biochemical Pharmacology · doi:10.1016/0006-2952(89)90338-9 · Cited by 522
Metadata
- Authors
- Reinke, L. A., Lai, E. K., DuBose, C. M., & McCay, P. B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1987-12
- Volume
- 84
- Issue
- 24
- Pages
- 9223-9227
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1992813824
- Cited by
- 237
- References
- 1
- FWCI
- 8.84
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Reinke, L. A., Lai, E. K., DuBose, C. M., & McCay, P. B. (1987). Reactive free radical generation in vivo in heart and liver of ethanol-fed rats: correlation with radical formation in vitro. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.84.24.9223
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
