The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Evolutionary relationship between the natural anti-Gal antibody and the Gal alpha 1----3Gal epitope in primates.
Open accessAbstract
Anti-Gal is a natural antibody, which constitutes as much as 1% of circulating IgG in humans and displays a distinct specificity for the structure Gal alpha 1----3Gal. This glycosidic structure has been found on various tissues of many nonprimate mammals. A comparative study of the occurrence of anti-Gal versus the expression of the Gal alpha 1----3Gal epitope was performed in primates, and a distinct evolutionary pattern was observed. Whereas anti-Gal was found to be present in Old World monkeys and apes in titers comparable to those in humans, its corresponding antigenic epitope is abundantly expressed on erythrocytes of New World monkeys. Immunostaining with anti-Gal of glycolipids from New World monkey erythrocytes indicated that the molecules to which anti-Gal binds are similar to those found in rabbit and bovine erythrocytes. These findings indicate that there is an evolutionary reciprocity between New World and Old World primates in the production of the Gal alpha 1----3Gal structure and the antibody that recognizes it. The expression of the Gal alpha 1----3Gal epitope was evolutionarily conserved in New World monkeys, but it was suppressed in ancestral lineages of Old World primates. The suppression of this epitope was accompanied by the production of anti-Gal. The observed in vivo binding of anti-Gal to human normal senescent and some pathologic erythrocytes implies that the Gal alpha 1----3Gal epitope is present in man in a cryptic form.
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Cites
A unique natural human IgG antibody with anti-alpha-galactosyl specificity.
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Chemistry of Lipid of the Posthemolytic Residue or Stroma of Erythrocytes
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Cited by
Galili, U., Shohet, S. B., Kobrin, E., Stults, C. L., & Macher, B. A. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)77900-9 · Cited by 817
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Thall, A. D., Malý, P., & Lowe, J. B. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.37.21437 · Cited by 401
Macher, B. A., & Galili, U. (2008) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2007.11.003 · Cited by 404
Self-citationTHE ??-1,3-GALACTOSYLTRANSFERASE KNOCKOUT MOUSE: Implications for Xenotransplantation1
Tearle, R. G., Tange, M. J., Zannettino, Z. L., Katerelos, M., Shinkel, T. A., Van Denderen, B. J. W., Lonie, A. J., Lyons, I., Nottle, M. B., Cox, T., et al. (1996) · Transplantation · doi:10.1097/00007890-199601150-00004 · Cited by 306
Metadata
- Authors
- Galili, U., Clark, M. R., Shohet, S. B., Buehler, J., & Macher, B. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1987-03
- Volume
- 84
- Issue
- 5
- Pages
- 1369-1373
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2078854426
- Cited by
- 549
- References
- 19
- FWCI
- 4.42
- Type
- journal article
- Language
- en
- Open access
- green
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- Galili, U., Clark, M. R., Shohet, S. B., Buehler, J., & Macher, B. A. (1987). Evolutionary relationship between the natural anti-Gal antibody and the Gal alpha 1----3Gal epitope in primates. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.84.5.1369
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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