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Characterization of the TPR-MET oncogene p65 and the MET protooncogene p140 protein-tyrosine kinases.
Open accessAbstract
The proteins encoded by the human TPR-MET oncogene (p 65tpr-met) and the human MET protooncogene (p140met) have been identified. The p65tpr-met and p140met, as well as a truncated TPR-MET product expressed in Escherichia coli, p50met, are autophosphorylated in vitro on tyrosine residues. Using the immunocomplex kinase assay, p140met activity was detected in various human tumor epithelial cell lines. In vivo, p65tpr-met is phosphorylated on both serine and tyrosine residues, while p140met is phosphorylated on serine and threonine. p140met is labeled by cell-surface iodination procedures, suggesting that it is a receptor-like transmembrane protein-tyrosine kinase.
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Bussolino, F., Di Renzo, M. F., Ziche, M., Bocchietto, E., Olivero, M., Naldini, L., Gaudino, G., Tamagnone, L., Coffer, A., & Comoglio, P. M. (1992) · The Journal of cell biology · doi:10.1083/jcb.119.3.629 · Cited by 1,337
Ponzetto, C., Bardelli, A., Zhen, Z., Maina, F., dalla Zonca, P., Giordano, S., Graziani, A., Panayotou, G., & Comoglio, P. M. (1994) · Cell · doi:10.1016/0092-8674(94)90318-2 · Cited by 991
Sonnenberg, E., Meyer, D., Weidner, K. M., & Birchmeier, C. (1993) · The Journal of cell biology · doi:10.1083/jcb.123.1.223 · Cited by 698
HGF/SF Is Present in Normal Adult Skeletal Muscle and Is Capable of Activating Satellite Cells
Tatsumi, R., Anderson, J. E., Nevoret, C. J., Halevy, O., & Allen, R. E. (1998) · Developmental Biology · doi:10.1006/dbio.1997.8803 · Cited by 686
Nakajima, M., Sawada, H., Yamada, Y., Watanabe, A., Tatsumi, M., Yamashita, J., Matsuda, M., Sakaguchi, T., Hirao, T., & Nakano, H. (1999) · Cancer · doi:10.1002/(sici)1097-0142(19990501)85:9%3c1894::aid-cncr3%3e3.0.co;2-j · Cited by 494
Metadata
- Authors
- Gonzatti-Haces, M., Seth, A., Park, M., Copeland, T., Oroszlan, S., & Vande Woude, G. F.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1988-01
- Volume
- 85
- Issue
- 1
- Pages
- 21-25
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2164884227
- Cited by
- 177
- References
- 0
- FWCI
- 6.11
- Type
- journal article
- Language
- en
- Open access
- green
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- Gonzatti-Haces, M., Seth, A., Park, M., Copeland, T., Oroszlan, S., & Vande Woude, G. F. (1988). Characterization of the TPR-MET oncogene p65 and the MET protooncogene p140 protein-tyrosine kinases. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.85.1.21
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