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Stress proteins are immune targets in leprosy and tuberculosis.
Open accessAbstract
To understand the immune response to infection by tuberculosis and leprosy bacilli and to develop improved vaccines, the nature of antigens that are involved in humoral and cell-mediated immunity was investigated. We have determined that five immunodominant protein antigens under study are homologues of stress proteins. This finding and observations with other pathogens suggest that infectious agents may respond to the host environment by producing stress proteins and that these proteins can be important immune targets. We postulate that abundant and highly conserved stress proteins may have "immunoprophylactic" potential for a broad spectrum of human pathogens.
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Citations
Cited by
COMMUNICATION MODULES IN BACTERIAL SIGNALING PROTEINS
Parkinson, J. S., & Kofoid, E. C. (1992) · Annual Review of Genetics · doi:10.1146/annurev.ge.26.120192.000443 · Cited by 1,450
Mycobacterium tuberculosis Pathogenesis and Molecular Determinants of Virulence
Smith, I. (2003) · Clinical Microbiology Reviews · doi:10.1128/cmr.16.3.463-496.2003 · Cited by 1,154
Cell Wall and Secreted Proteins of Candida albicans: Identification, Function, and Expression
Chaffin, W. L., López-Ribot, J. L., Casanova, M., Gozalbo, D., & Martínez, J. P. (1998) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.62.1.130-180.1998 · Cited by 726
Narberhaus, F. (2002) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.66.1.64-93.2002 · Cited by 538
Autoimmunity, microbial immunity and the immunological homunculus
Cohen, I. R., & Young, D. B. (1991) · Immunology Today · doi:10.1016/0167-5699(91)90093-9 · Cited by 502
Self-citation
Metadata
- Authors
- Young, D., Lathigra, R., Hendrix, R., Sweetser, D., & Young, R. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1988-06
- Volume
- 85
- Issue
- 12
- Pages
- 4267-4270
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2023871230
- Cited by
- 433
- References
- 0
- FWCI
- 22.49
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Stress proteins are immune targets in leprosy and tuberculosis. https://app.cochat.ai/papers/10.1073/pnas.85.12.4267
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- Young, D., Lathigra, R., Hendrix, R., Sweetser, D., & Young, R. A. (1988). Stress proteins are immune targets in leprosy and tuberculosis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.85.12.4267
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
