The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Neurofilament and tubulin expression recapitulates the developmental program during axonal regeneration: induction of a specific beta-tubulin isotype.
Open accessAbstract
We examined the differential expression of genes encoding three beta-tubulin isotypes (classes I, II, and IV) and the 68-kDa neurofilament protein (NF68) in rat sensory neurons during development, maturation, and axonal regeneration. Expression of the specific beta-tubulin gene encoding the class II isotype was induced to high levels during development and axonal regeneration, whereas the expression of genes encoding the two other isotypes (classes I and IV) remained comparable to mature levels. Conversely, expression of the NF68 gene was relatively low during development and regeneration. Thus, the developmental program for cytoskeletal gene expression is recapitulated during axonal regeneration. The high level of class II beta-tubulin expression found in developing and regenerating neurons occurs during the longitudinal growth of axons. In contrast, induction of NF68 gene expression is associated with the radial growth of axons in maturing neurons.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
Chirgwin, J. M., Przybyla, A. E., MacDonald, R. J., & Rutter, W. J. (1979) · Biochemistry · doi:10.1021/bi00591a005 · Cited by 21,725
Hoffman, P. N., & Lasek, R. J. (1975) · The Journal of cell biology · doi:10.1083/jcb.66.2.351 · Cited by 937
Self-citationULTRASTRUCTURE AND FUNCTION OF GROWTH CONES AND AXONS OF CULTURED NERVE CELLS
Yamada, K. M., Spooner, B. S., & Wessells, N. K. (1971) · The Journal of Cell Biology · doi:10.1083/jcb.49.3.614 · Cited by 767
Neurofilament gene expression: a major determinant of axonal caliber.
Hoffman, P. N., Cleveland, D. W., Griffin, J. W., Landes, P. W., Cowan, N. J., & Price, D. L. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.10.3472 · Cited by 719
Self-citationAxon caliber related to neurofilaments and microtubules in sciatic nerve fibers of rats and mice
Friede, R. L., & Samorajski, T. (1970) · The Anatomical Record · doi:10.1002/ar.1091670402 · Cited by 536
Control of axonal caliber by neurofilament transport.
Hoffman, P. N., Griffin, J. W., & Price, D. L. (1984) · The Journal of cell biology · doi:10.1083/jcb.99.2.705 · Cited by 440
Self-citationSullivan, K. F., & Cleveland, D. W. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.12.4327 · Cited by 400
Self-citationShank, P. R., Hughes, S. H., Kung, H.-J., Majors, J. E., Quintrell, N., Guntaka, R. V., Bishop, J. M., & Varmus, H. E. (1978) · Cell · doi:10.1016/0092-8674(78)90063-6 · Cited by 383
Kemphues, K. J., Kaufman, T. C., Raff, R. A., & Raff, E. C. (1982) · Cell · doi:10.1016/0092-8674(82)90321-x · Cited by 285
MICROTUBULES AND FILAMENTS IN THE AXONS AND ASTROCYTES OF EARLY POSTNATAL RAT OPTIC NERVES
Peters, A., & Vaughn, J. E. (1967) · The Journal of Cell Biology · doi:10.1083/jcb.32.1.113 · Cited by 285
Cited by
The cellular and molecular basis of peripheral nerve regeneration
Fu, S. Y., & Gordon, T. (1997) · Molecular Neurobiology · doi:10.1007/bf02740621 · Cited by 1,202
Neurofilaments and Neurofilament Proteins in Health and Disease
Yuan, A., Rao, M. V., Veeranna, & Nixon, R. A. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018309 · Cited by 731
Nerve Injury, Axonal Degeneration and Neural Regeneration: Basic Insights
Stoll, G., & Müller, H. W. (1999) · Brain Pathology · doi:10.1111/j.1750-3639.1999.tb00229.x · Cited by 599
Smith, D. S., & Pate Skene, J. H. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-02-00646.1997 · Cited by 494
Sulaiman, O. A. R., & Gordon, T. (2000) · Glia · doi:10.1002/1098-1136(200012)32:3<234::aid-glia40>3.0.co;2-3 · Cited by 340
Metadata
- Authors
- Hoffman, P. N., & Cleveland, D. W.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1988-06
- Volume
- 85
- Issue
- 12
- Pages
- 4530-4533
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2008094802
- Cited by
- 276
- References
- 24
- FWCI
- 5.25
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Neurofilament and tubulin expression recapitulates the developmental program during axonal regeneration: induction of a specific beta-tubulin isotype. https://app.cochat.ai/papers/10.1073/pnas.85.12.4530
- The paper
- Hoffman, P. N., & Cleveland, D. W. (1988). Neurofilament and tubulin expression recapitulates the developmental program during axonal regeneration: induction of a specific beta-tubulin isotype. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.85.12.4530
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
