MICROTUBULES AND FILAMENTS IN THE AXONS AND ASTROCYTES OF EARLY POSTNATAL RAT OPTIC NERVES
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Changes in the population of microtubules and filaments within the cytoplasm of maturing axons and astrocytes have been studied during the early postnatal development of rat optic nerves. At birth, all of the axons are unmyelinated; most have a diameter of 0.2–0.3 µ and contain 4–10 microtubules. Neurofilaments do not occur with any frequency until about 5 days postnatal when they appear as individual groups, each containing 4–12. Subsequently, the neurofilaments of each group disperse so that they become more evenly distributed in mature axons. Developing astrocytes show similar but rather more dramatic changes. Most astrocytic processes contain only microtubules at birth, but during maturation filaments begin to appear in increasing numbers while microtubules become less common. This process continues until, in the mature fibrous astrocytes, filaments pack the cytoplasm and microtubules are rare. These observations suggest that the filaments within axons and astrocytes may be formed by the breakdown of microtubules.
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Microtubules are apt to be especially important in neuronal development because they arise early, usually much before neurofilaments, and because they have been implicated in outgrowth of neuronal processes and transport within axons and dendrites.
“In this regard, microtubules are apt to be especially important because they arise early in neuronal development, usually much before neurofilaments (Pachter and Liem, 1984;Peters and Vaughn, 1967;Shaw et al., 1985), and because they have been implicated in a variety of cellular events, including the outgrowth of neuronal processes and the transport of materials within axons and dendrites.”
From Immunocytochemical localization of tubulin and microtubule-associated protein 2 during the development of hippocampal neurons in culture (1986) · cites this paper as Peters and Vaughn, 1967
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Caceres, A., Banker, G., & Binder, L. (1986) · The Journal of Neuroscience · doi:10.1523/jneurosci.06-03-00714.1986 · Cited by 367 · see citing works
“(Pachter and Liem, 1984; Peters and Vaughn, 1967; Shaw et al., 1985), and because they have been implicated in a variety of cellular events, including the outgrowth of neuronal processes and the transport of materials within axons and dendrites.”
BackgroundSchiweck, J., Eickholt, B. J., & Murk, K. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00261 · Cited by 223 · see citing works
The differential appearance of neurofilament triplet polypeptides in the developing rat optic nerve
Pachter, J. S., & Liem, R. K. H. (1984) · Developmental Biology · doi:10.1016/0012-1606(84)90021-6 · Cited by 175 · see citing works
- Authors
- Peters, A., & Vaughn, J. E.
- Affiliations
- University of Edinburgh (GB)
- ORCID
- Peters, Alan
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 1967-01-01
- Volume
- 32
- Issue
- 1
- Pages
- 113-119
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- PMC
- PMC2107085
- OpenAlex
- W2080155952
- Cited by
- 285
- References
- 0
- Citations by year
- 2026: 3 · 2024: 1 · 2023: 2 · 2022: 5 · 2020: 5 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 4
- FWCI
- 15.77
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by-nc-sa
- Locations
- The Journal of Cell Biology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- microtubules, neurofilaments, axons, astrocytes, optic nerve, postnatal development, cytoskeleton, unmyelinated axons, rats
- MeSH terms
- Animals, Animals, Newborn, Astrocytes, Axons, Actin Cytoskeleton, Microscopy, Electron, Microtubules, Optic Nerve, Rats
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