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Crosstalk between bacterial chemotaxis signal transduction proteins and regulators of transcription of the Ntr regulon: evidence that nitrogen assimilation and chemotaxis are controlled by a common phosphotransfer mechanism.
Open accessAbstract
We demonstrate by using purified bacterial components that the protein kinases that regulate chemotaxis and transcription of nitrogen-regulated genes, CheA and NRII, respectively, have cross-specificities: CheA can phosphorylate the Ntr transcription factor NRI and thereby activate transcription from the nitrogen-regulated glnA promoter, and NRII can phosphorylate CheY. In addition, we find that a high intracellular concentration of a highly active mutant form of NRII can suppress the smooth-swimming phenotype of a cheA mutant. These results argue strongly that sensory transduction in the Ntr and Che systems involves a common protein phosphotransfer mechanism.
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Citations
Cited by
Coordinate Regulation and Sensory Transduction in the Control of Bacterial Virulence
Miller, J. F., Mekalanos, J. J., & Falkow, S. (1989) · Science · doi:10.1126/science.2537530 · Cited by 616
Phosphorylation of bacterial response regulator proteins by low molecular weight phospho-donors.
Lukat, G. S., McCleary, W. R., Stock, A. M., & Stock, J. B. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.2.718 · Cited by 481
Self-citationThe Histidine Protein Kinase Superfamily
Grebe, T. W., & Stock, J. B. (1999) · Advances in Microbial Physiology · doi:10.1016/s0065-2911(08)60167-8 · Cited by 379
Self-citationIdentification of the site of phosphorylation of the chemotaxis response regulator protein, CheY
Sanders, D. A., Gillece-Castro, B. L., Stock, A. M., Burlingame, A. L., & Koshland, D. E. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)88250-7 · Cited by 300
Self-citationIgo, M. M., Ninfa, A. J., Stock, J. B., & Silhavy, T. J. (1989) · Genes & Development · doi:10.1101/gad.3.11.1725 · Cited by 277
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Metadata
- Authors
- Ninfa, A. J., Ninfa, E. G., Lupas, A. N., Stock, A., Magasanik, B., & Stock, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1988-08
- Volume
- 85
- Issue
- 15
- Pages
- 5492-5496
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1982249278
- Cited by
- 216
- References
- 0
- FWCI
- 14.31
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Crosstalk between bacterial chemotaxis signal transduction proteins and regulators of transcription of the Ntr regulon: evidence that nitrogen assimilation and chemotaxis are controlled by a common phosphotransfer mechanism. https://app.cochat.ai/papers/10.1073/pnas.85.15.5492
- The paper
- Ninfa, A. J., Ninfa, E. G., Lupas, A. N., Stock, A., Magasanik, B., & Stock, J. (1988). Crosstalk between bacterial chemotaxis signal transduction proteins and regulators of transcription of the Ntr regulon: evidence that nitrogen assimilation and chemotaxis are controlled by a common phosphotransfer mechanism. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.85.15.5492
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
