The DOI matches its Crossref record.
An erythrocyte-specific DNA-binding factor recognizes a regulatory sequence common to all chicken globin genes.
Open accessAbstract
We have identified a protein present only in erythroid cells that binds to two adjacent sites within an enhancer region of the chicken beta-globin locus. Mutation of the sites, so that binding by the factor can no longer be detected in vitro, leads to a loss of enhancing ability, assayed by transient expression in primary erythrocytes. Binding sites for the erythroid-specific factor (Eryf1) are found within regulatory regions for all chicken globin genes. A strong Eryf1 binding site is also present within the enhancer of at least one human globin gene, and proteins from human erythroid cells (but not HeLa cells) bind to both the chicken and the human sites.
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Cited by
Pevny, L., Simon, M. C., Robertson, E., Klein, W. H., Tsai, S.-F., D'Agati, V., Orkin, S. H., & Costantini, F. (1991) · Nature · doi:10.1038/349257a0 · Cited by 1,308
The protein CTCF is required for the enhancer blocking activity of vertebrate insulators
Bell, A. C., West, A. G., & Felsenfeld, G. (1999) · Cell · doi:10.1016/s0092-8674(00)81967-4 · Cited by 1,101
Self-citationWeiss, M. J., Keller, G., & Orkin, S. H. (1994) · Genes & Development · doi:10.1101/gad.8.10.1184 · Cited by 541
Expression of an erythroid transcription factor in megakaryocytic and mast cell lineages
Martin, D. I. K., Zon, L. I., Mutter, G., & Orkin, S. H. (1990) · Nature · doi:10.1038/344444a0 · Cited by 455
Transcriptional activation and DNA binding by the erythroid factor GF-1/NF-E1/Eryf 1.
Martin, D. I., & Orkin, S. H. (1990) · Genes & Development · doi:10.1101/gad.4.11.1886 · Cited by 409
Metadata
- Authors
- Evans, T., Reitman, M., & Felsenfeld, G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1988-08
- Volume
- 85
- Issue
- 16
- Pages
- 5976-5980
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2089019735
- Cited by
- 504
- References
- 0
- FWCI
- 13.09
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: An erythrocyte-specific DNA-binding factor recognizes a regulatory sequence common to all chicken globin genes. https://app.cochat.ai/papers/10.1073/pnas.85.16.5976
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- Evans, T., Reitman, M., & Felsenfeld, G. (1988). An erythrocyte-specific DNA-binding factor recognizes a regulatory sequence common to all chicken globin genes. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.85.16.5976
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
