The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Mechanism of inhibitory effect of dextran sulfate and heparin on replication of human immunodeficiency virus in vitro.
Open accessAbstract
The sulfated polysaccharides dextran sulfate and heparin have proved to be potent and selective inhibitors of human immunodeficiency virus type 1 (HIV-1) in vitro. Dextran sulfate (Mr 5000) and heparin (Mr 15,000) completely protected MT-4 cells against HIV-1-induced cytopathogenicity at a concentration of 25 micrograms/ml. Their 50% inhibitory concentrations were 9.1 micrograms/ml (dextran sulfate) and 7.0 micrograms/ml (heparin), respectively. No toxicity for the host cells was observed with these compounds at a concentration of 625 micrograms/ml. The anti-HIV-1 activity of heparins of various molecular weights correlated well with their anticoagulant activity. On the other hand, with dextran sulfates of low molecular weight (5000, 8000) a significant inhibitory effect on HIV-1 was achieved at a concentration that was not markedly inhibitory to the blood coagulation process. Dextran sulfate and heparin were not inhibitory to HIV-1 reverse transcriptase unless they were used at concentrations in excess of those that inhibited HIV-1 replication. They were highly effective against HIV-1 replication even when present only during the 2-hr virus adsorption period. Studies using radiolabeled HIV-1 virions indicated that dextran sulfate and heparin inhibit virus adsorption to the host cells.
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The Efficacy of Azidothymidine (AZT) in the Treatment of Patients with AIDS and AIDS-Related Complex
Fischl, M. A., Richman, D. D., Grieco, M. H., Gottlieb, M. S., Volberding, P. A., Laskin, O. L., Leedom, J. M., Groopman, J. E., Mildvan, D., Schooley, R. T., et al. (1987) · New England Journal of Medicine · doi:10.1056/nejm198707233170401 · Cited by 2,995
Furman, P. A., Fyfe, J. A., St Clair, M. H., Weinhold, K., Rideout, J. L., Freeman, G. A., Lehrman, S. N., Bolognesi, D. P., Broder, S., & Mitsuya, H. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.21.8333 · Cited by 1,347
Cited by
Kilby, J. M., Hopkins, S., Venetta, T. M., DiMassimo, B., Cloud, G. A., Lee, J. Y., Alldredge, L., Hunter, E., Lambert, D., Bolognesi, D., et al. (1998) · Nature Medicine · doi:10.1038/3293 · Cited by 987
Molecular Targets for AIDS Therapy
Mitsuya, H., Yarchoan, R., & Broder, S. (1990) · Science · doi:10.1126/science.1699273 · Cited by 732
Hayashi, T., Hayashi, K., Maeda, M., & Kojima, I. (1996) · Journal of Natural Products · doi:10.1021/np960017o · Cited by 422
Hayashi (1996) · doi:10.1089/aid.1996.12.1463 · Cited by 320
De Clercq, E., Yamamoto, N., Pauwels, R., Balzarini, J., Witvrouw, M., De Vreese, K., Debyser, Z., Rosenwirth, B., Peichl, P., & Datema, R. (1994) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.38.4.668 · Cited by 296
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Metadata
- Authors
- Baba, M., Pauwels, R., Balzarini, J., Arnout, J., Desmyter, J., & De Clercq, E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1988-08
- Volume
- 85
- Issue
- 16
- Pages
- 6132-6136
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2020933095
- Cited by
- 465
- References
- 2
- FWCI
- 7.19
- Type
- journal article
- Language
- en
- Open access
- green
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- Baba, M., Pauwels, R., Balzarini, J., Arnout, J., Desmyter, J., & De Clercq, E. (1988). Mechanism of inhibitory effect of dextran sulfate and heparin on replication of human immunodeficiency virus in vitro. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.85.16.6132
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