The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Molecular Targets for AIDS Therapy
Abstract
The development of antiretroviral therapy against acquired immunodeficiency syndrome (AIDS) has been an intense research effort since the discovery of the causative agent, human immunodeficiency virus (HIV). A large array of drugs and biologic substances can inhibit HIV replication in vitro. Nucleoside analogs—particularly those belonging to the dideoxynucleoside family—can inhibit reverse transcriptase after anabolic phosphorylation. 3′-Azido-2′,3′-dideoxythymidine (AZT) was the first such drug tested in individuals with AIDS, and considerable knowledge of structure-activity relations has emerged for this class of drugs. However, virtually every step in the replication of HIV could serve as a target for a new therapeutic intervention. In the future, non-nucleoside-type drugs will likely become more important in the experimental therapy of AIDS, and antiretroviral therapy will exert major effects against the morbidity and mortality caused by HIV.
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Cites
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Self-citationMalim, M. H., Hauber, J., Le, S.-Y., Maizel, J. V., & Cullen, B. R. (1989) · Nature · doi:10.1038/338254a0 · Cited by 1,280
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Cited by
Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor
Kohlstaedt, L. A., Wang, J., Friedman, J. M., Rice, P. A., & Steitz, T. A. (1992) · Science · doi:10.1126/science.1377403 · Cited by 1,914
Crystal structure of the ribonuclease H domain of HIV-1 reverse transcriptase
Davies, J. F., Hostomska, Z., Hostomsky, Z., Jordan, S. R., & Matthews, D. A. (1991) · Science · doi:10.1126/science.1707186 · Cited by 570
2-Pyrone natural products and mimetics: isolation, characterisation and biological activity
McGlacken, G. P., & Fairlamb, I. J. S. (2005) · Natural Product Reports · doi:10.1039/b416651p · Cited by 357
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Metadata
- Authors
- Mitsuya, H., Yarchoan, R., & Broder, S.
- Venue
- Science
- Published
- 1990-09-28
- Volume
- 249
- Issue
- 4976
- Pages
- 1533-1544
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2072409481
- Cited by
- 732
- References
- 9
- FWCI
- 62.79
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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