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Cited by 225Neuroscience and Neuropharmacology ResearchRetinal Development and DisordersNicotinic Acetylcholine Receptors Study

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

Cholinergic amacrine cells of the rabbit retina contain glutamate decarboxylase and gamma-aminobutyrate immunoreactivity

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Brecha, N, Johnson, D, Peichl, L, Wässle, H·1988·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.85.16.6187PMC PMC281930
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Abstract

The transmitters acetylcholine and gamma-aminobutyrate (GABA) play critical roles in the formation of receptive-field properties of retinal ganglion cells. In rabbit retina, cholinergic amacrine and displaced amacrine cells were identified by immunohistochemical staining for the enzyme choline acetyltransferase and by their avid accumulation of the fluorescent dye 4',6-diamidino-2-phenylindole. Several GABA-immunoreactive and glutamate decarboxylase-immunoreactive cell types, including a prominent population of small, round amacrine and displaced amacrine cells, were also identified. Double-label experiments demonstrated that all amacrine and displaced amacrine cells that prominently accumulate 4',6-diamidino-2-phenylindole contain GABA and glutamate decarboxylase immunoreactivity. However, not all GABA-immunoreactive cells accumulate this dye. Quantitative analysis of the ganglion cell layer of whole mount preparations of the retina showed that choline acetyltransferase-immunoreactive cells and the majority of GABA-immunoreactive cells have a small, round shape and similar cell density profiles that parallel that of displaced amacrine cells. These studies establish that cholinergic cells are a major subpopulation of GABA-immunoreactive amacrine and displaced amacrine cells. The role these cells have in the formation of ganglion cell receptive-field properties may be parsimoniously explained by an excitatory postsynaptic action mediated by acetylcholine and an inhibitory presynaptic action mediated by GABA.

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Crossref · 10.1073/pnas.85.16.6187

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Metadata

Authors
Brecha, N., Johnson, D., Peichl, L., & Wässle, H.
Affiliations
University of California, Los Angeles (US)
ORCID
Peichl, L
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
1988-08
Volume
85
Issue
16
Pages
6187-6191
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.85.16.6187
PMC
PMC281930
OpenAlex
W2019521144
Cited by
225
References
44
Citations by year
2024: 6 · 2023: 2 · 2022: 2 · 2021: 6 · 2020: 7 · 2019: 1 · 2018: 3 · 2017: 5 · 2016: 5 · 2015: 4 · 2014: 2 · 2013: 4 · 2012: 6
FWCI
4.40
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Eye Institute (R01EY004067, EY 04067)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Keywords
cholinergic amacrine cells, displaced amacrine cells, glutamic acid decarboxylase, GABA, choline acetyltransferase, retinal ganglion cells, receptive fields, acetylcholine, GABAergic inhibition, cholinergic inhibition, rabbit retina
MeSH terms
Acetylcholine, Animals, Choline O-Acetyltransferase, gamma-Aminobutyric Acid, Glutamate Decarboxylase, Horseradish Peroxidase, Indoles, Parasympathetic Nervous System, Rabbits, Retina

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