The DOI matches its Crossref record.
Hereditary differences in the expression of the human glutathione transferase active on trans-stilbene oxide are due to a gene deletion.
Open accessAbstract
Glutathione transferase (GT; EC 2.5.1.18) mRNA levels were measured in human liver samples by using mouse and human cDNA clones that encode class-mu and class-alpha GT. Although all the RNA samples examined contained class-alpha GT mRNA, class-mu GT mRNA was found only in individuals whose peripheral leukocytes expressed GT activity on the substrate trans-stilbene oxide. The mouse class-mu cDNA clone was used to identify a human class-mu GT cDNA clone, lambda GTH411. The amino acid sequence of the GT encoded by lambda GTH411 is identical with the 23 residues determined for the human liver GT-mu isoenzyme and shares 76-81% identity with mouse and rat class-mu GT isoenzymes. The mouse and human class-mu GT cDNA inserts hybridize with multiple BamHI and EcoRI restriction fragments in the human genome. One of these hybridizing fragments is missing in the DNA of individuals who lack GT activity on trans-stilbene oxide. Hybridizations with nonoverlapping subfragments of lambda GTH411 suggest that there are at least three class-mu genes in the human genome. One of these genes appears to be deleted in individuals lacking GT activity on trans-stilbene oxide.
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Cited by
Common deletion polymorphisms in the human genome
McCarroll, S. A., Hadnott, T. N., Perry, G. H., Sabeti, P. C., Zody, M. C., Barrett, J. C., Dallaire, S., Gabriel, S. B., Lee, C., Daly, M. J., et al. (2006) · Nature Genetics · doi:10.1038/ng1696 · Cited by 701
Watson, M. (1998) · Carcinogenesis · doi:10.1093/carcin/19.2.275 · Cited by 668
Metadata
- Authors
- Seidegård, J., Vorachek, W. R., Pero, R. W., & Pearson, W. R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1988-10
- Volume
- 85
- Issue
- 19
- Pages
- 7293-7297
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2052447033
- Cited by
- 727
- References
- 0
- FWCI
- 4.19
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Hereditary differences in the expression of the human glutathione transferase active on trans-stilbene oxide are due to a gene deletion. https://app.cochat.ai/papers/10.1073/pnas.85.19.7293
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- Seidegård, J., Vorachek, W. R., Pero, R. W., & Pearson, W. R. (1988). Hereditary differences in the expression of the human glutathione transferase active on trans-stilbene oxide are due to a gene deletion. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.85.19.7293
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
