The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Human glutathione S-transferase P1 polymorphisms: relationship to lung tissue enzyme activity and population frequency distribution
Abstract
The association between glutathione S-transferase (GST) activity as measured by 1-chloro-2,4-dinitrobenzene (CDNB) conjugation and genotype at exon 5 and exon 6 of the human GSTP1 gene was investigated in normal lung tissue obtained from 34 surgical patients. These samples were genotyped for previously identified polymorphisms in exon 5 (Ile105Val) and exon 6 (Ala114Val) by PCR-RFLP and direct sequencing. GST enzyme activity was significantly lower among individuals with the 105 Val allele. Homozygous Ile/Ile samples (n = 18) had a mean cytosolic CDNB conjugating activity of 74.9 +/- 3.8 nmol/mg per min; heterozygotes (n = 13) had a mean specific activity of 62.1 +/- 4.2 nmol/mg per min and homozygous Val/Val (n = 3) had a mean specific activity of 52.5 +/- 4.5 nmol/mg per min. The CDNB conjugating activity measured for the Ile/Ile genotype group was significantly different from that observed in the Ile/Val group (P = 0.03), and from Ile/Val and Val/Val genotypes combined (P = 0.009). Mean GST activity values were consistently lower in individuals with genotypes containing the 105 valine allele, regardless of smoking exposure. Genotypes at codon 114 were also assessed but the mean GST activity was not significantly lower in individuals with the 114 valine allele. A new haplotype, present in two samples who were homozygous 105Ile and had a 114Val, was identified and proposed as GSTP1*D. Frequencies of the exon 5 and exon 6 polymorphisms were determined in samples obtained from European-Americans, African-Americans and Taiwanese. The differences observed were highly significant suggesting the possibility of GSTP1 genotype-associated, ethnic differences in cancer susceptibility and chemotherapeutic response.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 317,331
Habig, W. H., Pabst, M. J., & Jakoby, W. B. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42083-8 · Cited by 18,221
Pemble, S., Schroeder, K. R., Spencer, S. R., Meyer, D. J., Hallier, E., Bolt, H. M., Ketterer, B., & Taylor, J. B. (1994) · Biochemical Journal · doi:10.1042/bj3000271 · Cited by 1,296
Mannervik, B., Alin, P., Guthenberg, C., Jensson, H., Tahir, M. K., Warholm, M., & Jörnvall, H. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.21.7202 · Cited by 1,071
Harries, L. (1997) · Carcinogenesis · doi:10.1093/carcin/18.4.641 · Cited by 737
Seidegård, J., Vorachek, W. R., Pero, R. W., & Pearson, W. R. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.19.7293 · Cited by 727
Ali-Osman, F., Akande, O., Antoun, G., Mao, J.-X., & Buolamwini, J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.15.10004 · Cited by 713
Bell, D. A., Taylor, J. A., Paulson, D. F., Robertson, C. N., Mohler, J. L., & Lucier, G. W. (1993) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/85.14.1159 · Cited by 697
Nomenclature for human glutathione transferases
Mannervik, B., Awasthi, Y. C., Board, P. G., Hayes, J. D., Di Ilio, C., Ketterer, B., Listowsky, I., Morgenstern, R., Muramatsu, M., Pearson, W. R., et al. (1992) · Biochemical Journal · doi:10.1042/bj2820305 · Cited by 671
Glutathione Transferases and Cancer
Tsuchida, S., & Sato, K. (1992) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409239209082566 · Cited by 537
Cited by
Avogbe, P. H. (2004) · Carcinogenesis · doi:10.1093/carcin/bgh353 · Cited by 142
Munaka, M., Kohshi, K., Kawamoto, T., Takasawa, S., Nagata, N., Itoh, H., Oda, S., & Katoh, T. (2003) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-003-0439-5 · Cited by 132
Murdzoska, J., Devadason, S. G., Khoo, S.-K., Landau, L. I., Young, S., Goldblatt, J., Zhang, G., Le Souëf, P. N., & Hayden, C. M. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200812-1887oc · Cited by 43
Metadata
- Authors
- Watson, M.
- Venue
- Carcinogenesis
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-02-01
- Volume
- 19
- Issue
- 2
- Pages
- 275-280
- ISSN
- 0143-3334 (ISSN-L)
- 1460-2180
- OpenAlex
- W2063919832
- Cited by
- 668
- References
- 28
- FWCI
- 6.87
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Human glutathione S-transferase P1 polymorphisms: relationship to lung tissue enzyme activity and population frequency distribution. https://app.cochat.ai/papers/10.1093/carcin/19.2.275
- The paper
- Watson, M. (1998). Human glutathione S-transferase P1 polymorphisms: relationship to lung tissue enzyme activity and population frequency distribution. Carcinogenesis. https://doi.org/10.1093/carcin/19.2.275
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
