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Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells.

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Bowman, E J, Siebers, A, Altendorf, K·1988·Proceedings of the National Academy of Sciences

Abstract

Various membrane ATPases have been tested for their sensitivity to bafilomycin A1, a macrolide antibiotic. F1F0 ATPases from bacteria and mitochondria are not affected by this antibiotic. In contrast, E1E2 ATPases--e.g., the K+-dependent (Kdp) ATPase from Escherichia coli, the Na+,K+-ATPase from ox brain, and the Ca2+-ATPase from sarcoplasmic reticulum--are moderately sensitive to this inhibitor. Finally, membrane ATPases from Neurospora vacuoles, chromaffin granules, and plant vacuoles are extremely sensitive. From this we conclude that bafilomycin A1 is a valuable tool for distinguishing among the three different types of ATPases and represents the first relatively specific potent inhibitor of vacuolar ATPases.

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Metadata

Authors
Bowman, E. J., Siebers, A., & Altendorf, K.
Venue
Proceedings of the National Academy of Sciences
Published
1988-11
Volume
85
Issue
21
Pages
7972-7976
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2035501441
Cited by
1,784
References
0
FWCI
7.12
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells. https://app.cochat.ai/papers/10.1073/pnas.85.21.7972
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Bowman, E. J., Siebers, A., & Altendorf, K. (1988). Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.85.21.7972

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.