Identification of a factor that links apoptotic cells to phagocytes

Integrins: Versatility, modulation, and signaling in cell adhesion

Hynes, R. O. (1992) · Cell · doi:10.1016/0092-8674(92)90115-s · Cited by 9,857 · see citing works

Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis

Koopman, G., Reutelingsperger, C. P. M., Kuijten, G., Keehnen, R. M. J., Pals, S. T., & van Oers, M. H. J. (1994) · Blood · doi:10.1182/blood.v84.5.1415.1415 · Cited by 2,687 · see citing works

Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs

Albert, M. L., Sauter, B., & Bhardwaj, N. (1998) · Nature · doi:10.1038/32183 · Cited by 2,350 · see citing works

Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis

Koopman, G., Reutelingsperger, C., Kuijten, G., et al. (1994) · Blood · doi:10.1182/blood.v84.5.1415.bloodjournal8451415 · Cited by 2,068 · see citing works

Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells.

Bowman, E. J., Siebers, A., & Altendorf, K. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.21.7972 · Cited by 1,792 · see citing works

Corpse clearance defines the meaning of cell death

Savill, J., & Fadok, V. A. (2000) · Nature · doi:10.1038/35037722 · Cited by 1,535 · see citing works

A receptor for phosphatidylserine-specific clearance of apoptotic cells

Fadok, V. A., Bratton, D. L., Rose, D. M., Pearson, A. M., Ezekowitz, R. A. B., & Henson, P. M. (2000) · Nature · doi:10.1038/35011084 · Cited by 1,491 · see citing works

Phagocytosis and clearance of apoptotic cells is mediated by MER

Scott, R. S., McMahon, E. J., Pop, S. M., Reap, E. A., Caricchio, R., Cohen, P. L., Earp, H. S., & Matsushima, G. K. (2001) · Nature · doi:10.1038/35075603 · Cited by 1,215 · see citing works

C1q and Mannose Binding Lectin Engagement of Cell Surface Calreticulin and Cd91 Initiates Macropinocytosis and Uptake of Apoptotic Cells

Ogden, C. A., deCathelineau, A. M., Hoffmann, P. R., Bratton, D. L., Ghebrehiwet, B., Fadok, V. A., & Henson, P. M. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.6.781 · Cited by 1,148 · see citing works

Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis

Savill, J., Dransfield, I., Hogg, N., & Haslett, C. (1990) · Nature · doi:10.1038/343170a0 · Cited by 846 · see citing works

Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis.

Savill, J., Hogg, N., Ren, Y., & Haslett, C. (1992) · Journal of Clinical Investigation · doi:10.1172/jci116019 · Cited by 813 · see citing works

The role of phosphatidylserine in recognition of apoptotic cells by phagocytes

Fadok, V. A., Bratton, D. L., Frasch, S. C., Warner, M. L., & Henson, P. M. (1998) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400404 · Cited by 776 · see citing works

A Hierarchical Role for Classical Pathway Complement Proteins in the Clearance of Apoptotic Cells in Vivo

Taylor, P. R., Carugati, A., Fadok, V. A., Cook, H. T., Andrews, M., Carroll, M. C., Savill, J., Henson, P. M., Botto, M., & Walport, M. J. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.3.359 · Cited by 724 · see citing works

Loss of Phospholipid Asymmetry and Surface Exposure of Phosphatidylserine Is Required for Phagocytosis of Apoptotic Cells by Macrophages and Fibroblasts*

Fadok, V., de Cathelineau, A., Daleke, D. L., Henson, P., & Bratton, D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m003649200 · Cited by 689 · see citing works

Different populations of macrophages use either the vitronectin receptor or the phosphatidylserine receptor to recognize and remove apoptotic cells

Fadok, V. A., Savill, J., Haslett, C., Bratton, D. L., Doherty, D. E., Campbell, P. A., & Henson, P. M. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.149.12.4029 · Cited by 596 · see citing works

The Class B Scavenger Receptors SR-BI and CD36 Are Receptors for Anionic Phospholipids

Rigotti, A., Acton, S. L., & Krieger, M. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.27.16221 · Cited by 560 · see citing works

In vivo detection and imaging of phosphatidylserine expression during programmed cell death

Blankenberg, F. G., Katsikis, P. D., Tait, J. F., Davis, R. E., Naumovski, L., Ohtsuki, K., Kopiwoda, S. Y., Abrams, M. J., Darkes, M. C., Robbins, R. C., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6349 · Cited by 536 · see citing works

Requirement of DNase II for Definitive Erythropoiesis in the Mouse Fetal Liver

Kawane, K., Fukuyama, H., Kondoh, G., Takeda, J., Ohsawa, Y., Uchiyama, Y., & Nagata, S. (2001) · Science · doi:10.1126/science.292.5521.1546 · Cited by 387 · see citing works

Recognizing death: the phagocytosis of apoptotic cells

Platt, N., da Silva, R. P., & Gordon, S. (1998) · Trends in Cell Biology · doi:10.1016/s0962-8924(98)01329-4 · Cited by 375 · see citing works

cDNA cloning of a mouse mammary epithelial cell surface protein reveals the existence of epidermal growth factor-like domains linked to factor VIII-like sequences.

Stubbs, J. D., Lekutis, C., Singer, K. L., Bui, A., Yuzuki, D., Srinivasan, U., & Parry, G. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.21.8417 · Cited by 313 · see citing works

Cell Adhesion to Phosphatidylserine Mediated by a Product of Growth Arrest-specific Gene 6*

Nakano, T., Ishimoto, Y., Kishino, J., Umeda, M., Inoue, K., Nagata, K., Ohashi, K., Mizuno, K., & Arita, H. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.47.29411 · Cited by 264 · see citing works

Exposure of Phosphatidylethanolamine on the Surface of Apoptotic Cells

Emoto, K., Toyama‐Sorimachi, N., Karasuyama, H., Inoue, K., & Umeda, M. (1997) · Experimental Cell Research · doi:10.1006/excr.1997.3521 · Cited by 249 · see citing works

An auxiliary mode of apoptotic DNA fragmentation provided by phagocytesPreprint

McIlroy, D., Tanaka, M., Sakahira, H., Fukuyama, H., Suzuki, M., Yamamura, K., Ohsawa, Y., Uchiyama, Y., & Nagata, S. (2000) · Genes & Development · doi:10.1101/gad.14.5.549 · Cited by 193 · see citing works

Apoptosis

Hengartner, M. O. (2001) · Cell · doi:10.1016/s0092-8674(01)00219-7 · Cited by 185 · see citing works

Sterol Carrier Protein-2 Is Involved in Cholesterol Transfer from the Endoplasmic Reticulum to the Plasma Membrane in Human Fibroblasts

Puglielli, L., Rigotti, A., Greco, A. V., Santos, M. J., & Nervi, F. O. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.32.18723 · Cited by 168 · see citing works

Control of Milk Secretion and Apoptosis DuringMammary Involution

WILDE, C. J., Knight, C. H., & Flint, D. J. (1999) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1023/a:1018717006152 · Cited by 152 · see citing works

Bovine PAS-6/7 Binds αVβ5 Integrin and Anionic Phospholipids through Two Domains

Andersen, M. H., Berglund, L., Rasmussen, J. T., & Petersen, T. E. (1997) · Biochemistry · doi:10.1021/bi963119m · Cited by 121 · see citing works

Lactation-Dependent Expression of an mRNA Splice Variant with an Exon for a MultiplyO-Glycosylated Domain of Mouse Milk Fat Globule Glycoprotein MFG-E8

Oshima, K., Aoki, N., Negi, M., Kishi, M., Kitajima, K., & Matsuda, T. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.0107 · Cited by 81 · see citing works

Clearance: The Last and Often Forgotten Stage of Apoptosis

Fadok, V. A. (1999) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1023/a:1011384009787 · Cited by 75 · see citing works

Cloning of mouse integrin alphaV cDNA and role of the alphaV-related matrix receptors in metanephric development.

Wada, J., Kumar, A., Liu, J., Ruoslahti, E. I., Reichardt, L. F., Marvaldi, J. L., & Kanwar, Y. S. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.132.6.1161 · Cited by 65 · see citing works

Upstream stimulating factor-1 (USF1) and USF2 bind to and activate the promoter of theadenomatous polyposis coli (APC) tumor suppressor gene

Jaiswal, A. S., & Narayan, S. (2001) · Journal of Cellular Biochemistry · doi:10.1002/1097-4644(20010501)81:2 · Cited by 55 · see citing works

Systematic Peptide Fragmentation of Polyvinylidene Difluoride(PVDF)-Immobilized Proteins Prior to Microsequencing

Iwamatsu, A., & Yoshida-Kubomura, N. (1996) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a021389 · Cited by 53 · see citing works

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

Colombo, M., Raposo, G., & Théry, C. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101512-122326 · Cited by 6,186 · see citing works

Membrane vesicles as conveyors of immune responses

Théry, C., Ostrowski, M., & Segura, É. (2009) · Nature reviews. Immunology · doi:10.1038/nri2567 · Cited by 3,869 · see citing works

Robbins and Cotran Pathologic Basis of Disease

Hoda, S. A., & Hoda, R. S. (2020) · American Journal of Clinical Pathology · doi:10.1093/ajcp/aqaa163 · Cited by 3,369 · see citing works

Apoptosis: controlled demolition at the cellular level

Taylor, R. C., Cullen, S. P., & Martin, S. J. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2312 · Cited by 2,617 · see citing works

Routes and mechanisms of extracellular vesicle uptake

Mulcahy, L. A., Pink, R. C., & Carter, D. R. F. (2014) · Journal of Extracellular Vesicles · doi:10.3402/jev.v3.24641 · Cited by 2,832 · see citing works

A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease

the CARDIoGRAMplusC4D Consortium (2015) · Nature Genetics · doi:10.1038/ng.3396 · Cited by 2,447 · see citing works

Regulation of immune responses by extracellular vesicles

Robbins, P. D., & Morelli, A. E. (2014) · Nature Reviews Immunology · doi:10.1038/nri3622 · Cited by 2,260 · see citing works

Nonresolving Inflammation

Nathan, C., & Ding, A. (2010) · Cell · doi:10.1016/j.cell.2010.02.029 · Cited by 2,183 · see citing works

A blast from the past: clearance of apoptotic cells regulates immune responses

Savill, J., Dransfield, I., Gregory, C. D., & Haslett, C. (2002) · Nature reviews. Immunology · doi:10.1038/nri957 · Cited by 1,574 · see citing works

Overview of cell death signaling pathways

Jin, Z., & El‐Deiry, W. S. (2005) · Cancer Biology & Therapy · doi:10.4161/cbt.4.2.1508 · Cited by 1,323 · see citing works

Apoptotic cell clearance: basic biology and therapeutic potential

Poon, I. K. H., Lucas, C. D., Rossi, A. G., & Ravichandran, K. S. (2014) · Nature Reviews Immunology · doi:10.1038/nri3607 · Cited by 1,223 · see citing works

Identification of Tim4 as a phosphatidylserine receptor

Miyanishi, M., Tada, K., Koike, M., Uchiyama, Y., Kitamura, T., & Nagata, S. (2007) · Nature · doi:10.1038/nature06307 · Cited by 1,180 · see citing works

Immunogenic and tolerogenic cell death

Green, D. R., Ferguson, T., Zitvogel, L., & Kroemer, G. (2009) · Nature Reviews Immunology · doi:10.1038/nri2545 · Cited by 1,176 · see citing works

Apoptosis and Clearance of Apoptotic Cells

Nagata, S. (2018) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042617-053010 · Cited by 1,107 · see citing works

Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells

Morelli, A. E., Larregina, A. T., Shufesky, W. J., Sullivan, M. L. G., Stolz, D. B., Papworth, G. D., Zahorchak, A. F., Logar, A., Wang, Z., Watkins, S. C., et al. (2004) · Blood · doi:10.1182/blood-2004-03-0824 · Cited by 1,075 · see citing works

The Cell Biology of Phagocytosis

Flannagan, R. S., Jaumouillé, V., & Grinstein, S. (2011) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-011811-132445 · Cited by 1,016 · see citing works

Autoimmune Disease and Impaired Uptake of Apoptotic Cells in MFG-E8-Deficient Mice

Hanayama, R., Tanaka, M., Miyasaka, K., Aozasa, K., Koike, M., Uchiyama, Y., & Nagata, S. (2004) · Science · doi:10.1126/science.1094359 · Cited by 992 · see citing works

Calcium-dependent phospholipid scrambling by TMEM16F

Suzuki, J., Umeda, M., Sims, P. J., & Nagata, S. (2010) · Nature · doi:10.1038/nature09583 · Cited by 982 · see citing works

The Phagocytic Function of Macrophage-Enforcing Innate Immunity and Tissue Homeostasis

Hirayama, D., Iida, T., & Nakase, H. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms19010092 · Cited by 927 · see citing works

Microglial Phagocytosis of Live Neurons

Brown, G. C., & Neher, J. J. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3710 · Cited by 853 · see citing works

Autoimmunity and the Clearance of Dead Cells

Nagata, S., Hanayama, R., & Kawane, K. (2010) · Cell · doi:10.1016/j.cell.2010.02.014 · Cited by 877 · see citing works

Focus on Extracellular Vesicles: Introducing the Next Small Big Thing

Kalra, H., Drummen, G. P. C., & Mathivanan, S. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17020170 · Cited by 865 · see citing works

Microglia: Scapegoat, saboteur, or something else?

Aguzzi, A., Barres, B. A., & Bennett, M. L. (2013) · Science · doi:10.1126/science.1227901 · Cited by 836 · see citing works

An Apoptotic ‘Eat Me’ Signal: Phosphatidylserine Exposure

Segawa, K., & Nagata, S. (2015) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.08.003 · Cited by 778 · see citing works

Kidney injury molecule–1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells

Ichimura, T., van Asseldonk, E. J. P., Humphreys, B. D., Gunaratnam, L., Duffield, J. S., & Bonventre, J. V. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34487 · Cited by 768 · see citing works

Apoptosis: a basic biological phenomenon with wide‐ranging implications in human disease

Fadeel, B., & Orrenius, S. (2005) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2005.01570.x · Cited by 699 · see citing works

Apoptotic Cells Promote Their Own Clearance and Immune Tolerance through Activation of the Nuclear Receptor LXR

A-González, N., Bensinger, S. J., Hong, C., Beceiro, S., Bradley, M. N., Zelcer, N., Deniz, J. M., Ramírez, C. M., Díaz, M., Gallardo, G., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.06.018 · Cited by 674 · see citing works

Phagocytosis: Our Current Understanding of a Universal Biological Process

Uribe-Querol, E., & Rosales, C. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01066 · Cited by 651 · see citing works

Phagocytosis

Stuart, L. M., & Ezekowitz, R. A. B. (2005) · Immunity · doi:10.1016/j.immuni.2005.05.002 · Cited by 667 · see citing works

TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells.

Kobayashi, N., Karisola, P., Peña-Cruz, V., Dorfman, D., Jinushi, M., Umetsu, S., Butte, M., Nagumo, H., Chernova, I., Zhu, B., et al. (2007) · Immunity · doi:10.1016/j.immuni.2007.11.011 · Cited by 688 · see citing works

Consequences and Therapeutic Implications of Macrophage Apoptosis in Atherosclerosis

Tabas, I. A. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000184783.04864.9f · Cited by 641 · see citing works

Engulfment of apoptotic cells: signals for a good meal

Ravichandran, K. S., & Lorenz, U. M. (2007) · Nature reviews. Immunology · doi:10.1038/nri2214 · Cited by 634 · see citing works

The Retinal Pigment Epithelium in Health and Disease

Sparrrow, J. R., Hicks, D., & Hamel, C. (2010) · Current Molecular Medicine · doi:10.2174/156652410793937813 · Cited by 625 · see citing works

ICAM-1 on exosomes from mature dendritic cells is critical for efficient naive T-cell priming

Segura, É., Nicco, C., Lombard, B., Véron, P., Raposo, G., Batteux, F., Amigorena, S., & Théry, C. (2005) · Blood · doi:10.1182/blood-2005-01-0220 · Cited by 614 · see citing works

Exosomes and their roles in immune regulation and cancer

Greening, D. W., Gopal, S. K., Xu, R., Simpson, R. J., & Chen, W. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.02.009 · Cited by 608 · see citing works

Diagnosing and exploiting cancer's addiction to blocks in apoptosis

Letai, A. G. (2008) · Nature reviews. Cancer · doi:10.1038/nrc2297 · Cited by 577 · see citing works

Phagocytosis: Receptors, signal integration, and the cytoskeleton

Freeman, S. A., & Grinstein, S. (2014) · Immunological Reviews · doi:10.1111/imr.12212 · Cited by 548 · see citing works

Xk-Related Protein 8 and CED-8 Promote Phosphatidylserine Exposure in Apoptotic Cells

Suzuki, J., Denning, D. P., Imanishi, E., Horvitz, H. R., & Nagata, S. (2013) · Science · doi:10.1126/science.1236758 · Cited by 573 · see citing works

Beginnings of a Good Apoptotic Meal: The Find-Me and Eat-Me Signaling Pathways

Ravichandran, K. S. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.004 · Cited by 559 · see citing works

Exosomes: immune properties and potential clinical implementations

Chaput, N., & Théry, C. (2010) · Seminars in Immunopathology · doi:10.1007/s00281-010-0233-9 · Cited by 561 · see citing works

Clearance of Apoptotic Cells

Lauber, K., Blumenthal, S. G., Waibel, M., & Wesselborg, S. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00237-0 · Cited by 552 · see citing works

Phagocytosis: A Fundamental Process in Immunity

Rosales, C., & Uribe‐Querol, E. (2017) · BioMed Research International · doi:10.1155/2017/9042851 · Cited by 555 · see citing works

Find-me and eat-me signals in apoptotic cell clearance: progress and conundrums

Ravichandran, K. S. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20101157 · Cited by 547 · see citing works

Exosomes as intercellular signalosomes and pharmacological effectors

Record, M., Subra, C., Silvente‐Poirot, S., & Poirot, M. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.02.011 · Cited by 539 · see citing works

Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure

Segawa, K., Kurata, S., Yanagihashi, Y., Brummelkamp, T. R., Matsuda, F., & Nagata, S. (2014) · Science · doi:10.1126/science.1252809 · Cited by 528 · see citing works

Programmed cell death and the immune system

Nagata, S., & Tanaka, M. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2016.153 · Cited by 518 · see citing works

Current understanding of periodontal disease pathogenesis and targets for host‐modulation therapy

Hajishengallis, G., Chavakis, T., & Lambris, J. D. (2020) · Periodontology 2000 · doi:10.1111/prd.12331 · Cited by 513 · see citing works

Erythroblastic islands: niches for erythropoiesis

Chasis, J. A., & Mohandas, N. (2008) · Blood · doi:10.1182/blood-2008-03-077883 · Cited by 506 · see citing works

Clearing the Dead: Apoptotic Cell Sensing, Recognition, Engulfment, and Digestion

Hochreiter-Hufford, A., & Ravichandran, K. S. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008748 · Cited by 503 · see citing works

Clearance of apoptotic neutrophils and resolution of inflammation

Greenlee‐Wacker, M. C. (2016) · Immunological Reviews · doi:10.1111/imr.12453 · Cited by 478 · see citing works

A novel affinity-based method for the isolation of highly purified extracellular vesicles

Nakai, W., Yoshida, T., Díez, D., Miyatake, Y., Nishibu, T., Imawaka, N., Naruse, K., Sadamura, Y., & Hanayama, R. (2016) · Scientific Reports · doi:10.1038/srep33935 · Cited by 486 · see citing works

Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells

Jinushi, M., Chiba, S., Yoshiyama, H., Masutomi, K., Kinoshita, I., Dosaka-Akita, H., Yagita, H., Takaoka, A., & Tahara, H. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106645108 · Cited by 479 · see citing works

CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis

Truman, L. A., Ford, C. A., Pasikowska, M., Pound, J. D., Wilkinson, S. J., Dumitriu, I. E., Melville, L., Melrose, L. A., Ogden, C. A., Nibbs, R., et al. (2008) · Blood · doi:10.1182/blood-2008-06-162404 · Cited by 473 · see citing works

Targeting Tyro3, Axl and MerTK (TAM receptors): implications for macrophages in the tumor microenvironment

Myers, K. V., Amend, S. R., & Pienta, K. J. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1022-2 · Cited by 482 · see citing works

Kupffer Cell Engulfment of Apoptotic Bodies Stimulates Death Ligand and Cytokine Expression

Canbay, A. E., Feldstein, A. E., Higuchi, H., Werneburg, N., Grambihler, A., Bronk, S. F., & Gores, G. J. (2003) · Hepatology · doi:10.1053/jhep.2003.50472 · Cited by 469 · see citing works

Pathogenesis of Human Systemic Lupus Erythematosus: A Cellular Perspective

Moulton, V. R., Suárez‐Fueyo, A., Meidan, E., Li, H., Mizui, M., & Tsokos, G. C. (2017) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2017.05.006 · Cited by 478 · see citing works

Rapid cell corpse clearance by stabilin-2, a membrane phosphatidylserine receptor

Park, S.-Y., Jung, M.-Y., Kim, H.-J., Lee, S., Kim, S.-Y., Lee, B.-H., Kwon, T.-H., Park, R. W., & Kim, I. T. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402242 · Cited by 464 · see citing works

CD169-Positive Macrophages Dominate Antitumor Immunity by Crosspresenting Dead Cell-Associated Antigens

Asano, K., Nabeyama, A., Miyake, Y., Qiu, C., Kurita, A., Tomura, M., Kanagawa, O., Fujii, S., & Tanaka, M. (2010) · Immunity · doi:10.1016/j.immuni.2010.12.011 · Cited by 454 · see citing works

Degradation of chromosomal DNA during apoptosis

Nagata, S., Nagase, H., Kawane, K., Mukae, N., & Fukuyama, H. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401161 · Cited by 454 · see citing works

Getting to the Outer Leaflet: Physiology of Phosphatidylserine Exposure at the Plasma Membrane

Bevers, E. M., & Williamson, P. L. (2016) · Physiological Reviews · doi:10.1152/physrev.00020.2015 · Cited by 444 · see citing works

How macrophages deal with death

Lemke, G. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0167-y · Cited by 437 · see citing works

Annexin I Is an Endogenous Ligand that Mediates Apoptotic Cell Engulfment

Arur, S., Uche, U. E., Rezaul, K., Fong, M., Scranton, V., Cowan, A. E., Mohler, W., & Han, D. K. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00090-x · Cited by 434 · see citing works

Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation

NAKAYAMA, M., Akiba, H., Takeda, K., Kojima, Y., Hashiguchi, M., Azuma, M., Yagita∥, H., & Okumura, K. (2009) · Blood · doi:10.1182/blood-2008-10-185884 · Cited by 434 · see citing works

Macrophages: The Good, the Bad, and the Gluttony

Ross, E. A., Devitt, A., & Johnson, J. R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.708186 · Cited by 436 · see citing works

Phagocytosis of Retinal Rod and Cone Photoreceptors

Kevany, B. M., & Palczewski, K. (2010) · Physiology · doi:10.1152/physiol.00038.2009 · Cited by 426 · see citing works

Exosomes as Potent Cell-Free Peptide-Based Vaccine. I. Dendritic Cell-Derived Exosomes Transfer Functional MHC Class I/Peptide Complexes to Dendritic Cells

André, F., Chaput, N., Schartz, N. E. C., Flament, C., Aubert, N., Bernard, J., Lemonnier, F., Raposo, G., Escudier, B., Hsu, D.-H., et al. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.4.2126 · Cited by 496 · see citing works

Exosomes: Mechanisms of Uptake

McKelvey, K. J., Powell, K., Ashton, A. W., Morris, J. M., & McCracken, S. A. (2015) · Journal of Circulating Biomarkers · doi:10.5772/61186 · Cited by 421 · see citing works

Breast milk oligosaccharides: structure-function relationships in the neonate

Smilowitz, J. T., Lebrilla, C. B., Mills, D. A., German, J. B., & Freeman, S. L. (2014) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071813-105721 · Cited by 410 · see citing works

Serum-derived protein S binds to phosphatidylserine and stimulates the phagocytosis of apoptotic cells

Anderson, H. A., Maylock, C. A., Williams, J. A., Paweletz, C. P., Shu, H., & Shacter, E. B. (2002) · Nature Immunology · doi:10.1038/ni871 · Cited by 405 · see citing works

Phosphatidylserine Receptor Is Required for Clearance of Apoptotic Cells

Li, M. O., Sarkisian, M. R., Mehal, W. Z., RAKIC, P. T., & Flavell, R. A. (2003) · Science · doi:10.1126/science.1087621 · Cited by 403 · see citing works

Cellular microparticles: what are they bad or good for?

Freyssinet, J. M. (2003) · Journal of Thrombosis and Haemostasis · doi:10.1046/j.1538-7836.2003.00309.x · Cited by 399 · see citing works

Follicular Dendritic Cells Emerge from Ubiquitous Perivascular Precursors

Kräutler, N. J., Kana, V., Kranich, J., Tian, Y., Perera, D., Lemm, D., Schwarz, P., Armulik, A., Browning, J. L., Tallquist, M. D., et al. (2012) · Cell · doi:10.1016/j.cell.2012.05.032 · Cited by 397 · see citing works

Aminophospholipid Asymmetry: A Matter of Life and Death

Balasubramanian, K., & Schroit, A. J. (2003) · Annual Review of Physiology · doi:10.1146/annurev.physiol.65.092101.142459 · Cited by 396 · see citing works

Inhibition of Microglial Phagocytosis Is Sufficient To Prevent Inflammatory Neuronal Death

Neher, J. J., Neniskyte, U., Zhao, J.-W., Bal-Price, A., Tolkovsky, A. M., & Brown, G. C. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003600 · Cited by 373 · see citing works

Molecular interactions at the surface of extracellular vesicles

Buzás, E. I., Tóth, E. Á., Sódar, B. W., & Szabó-Taylor, K. (2018) · Seminars in Immunopathology · doi:10.1007/s00281-018-0682-0 · Cited by 384 · see citing works

Circulating Microparticles

Boulanger, C. M., Amabile, N., & Tedgui, A. (2006) · Hypertension · doi:10.1161/01.hyp.0000231507.00962.b5 · Cited by 372 · see citing works

Apoptotic neutrophils and T cells sequester chemokines during immune response resolution through modulation of CCR5 expression

Ariel, A., Fredman, G., Sun, Y., Kantarcı, A., Dyke, T. E. V., Luster, A. D., & Serhan, C. N. (2006) · Nature Immunology · doi:10.1038/ni1392 · Cited by 363 · see citing works

Phosphatidylserine-dependent engulfment by macrophages of nuclei from erythroid precursor cells

Yoshida, H., Kawane, K., Koike, M., Mori, Y., Uchiyama, Y., & Nagata, S. (2005) · Nature · doi:10.1038/nature03964 · Cited by 346 · see citing works

Phagocytosis executes delayed neuronal death after focal brain ischemia

Neher, J. J., Emmrich, J., Fricker, M., Mander, P. K., Théry, C., & Brown, G. C. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1308679110 · Cited by 350 · see citing works

Resolution of organ fibrosis

Jun, J.-I., & Lau, L. F. (2018) · Journal of Clinical Investigation · doi:10.1172/jci93563 · Cited by 348 · see citing works

Oxidative lipidomics of apoptosis: redox catalytic interactions of cytochrome c with cardiolipin and phosphatidylserine

Kagan, V. E., Borisenko, G. G., Tyurina, Y. Y., Tyurin, V. A., Jiang, J., Potapovich, A. I., Kini, V., Amoscato, A. A., & Fujii, Y. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.08.016 · Cited by 342 · see citing works

Phosphatidylserine recognition by phagocytes: a view to a kill

Wu, Y., Tibrewal, N., & Birge, R. B. (2006) · Trends in Cell Biology · doi:10.1016/j.tcb.2006.02.003 · Cited by 341 · see citing works

Of macrophages and red blood cells; a complex love story

de Back, D. Z., Kostova, E., van Kraaij, M., van den Berg, T. K., & van Bruggen, R. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00009 · Cited by 325 · see citing works

The Dynamics of Apoptotic Cell Clearance

Elliott, M. R., & Ravichandran, K. S. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.06.029 · Cited by 314 · see citing works

A novel method to determine the engulfment of apoptotic cells by macrophages using pHrodo succinimidyl ester

Miksa, M., Komura, H., Wu, R., Shah, K. G., & Wang, P. (2009) · Journal of Immunological Methods · doi:10.1016/j.jim.2008.11.019 · Cited by 320 · see citing works

Critical role of macrophages in the marginal zone in the suppression of immune responses to apoptotic cell–associated antigens

Miyake, Y., Asano, K., Kaise, H., Uemura, M., Nakayama, M., & Tanaka, M. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31990 · Cited by 320 · see citing works

Lactadherin promotes VEGF-dependent neovascularization

Silvestre, J., Théry, C., Hamard, G., Boddaert, J., Aguilar, B. A., Delcayre, A. X., Houbron, C., Tamarat, R., Blanc‐Brude, O., Heeneman, S., et al. (2005) · Nature Medicine · doi:10.1038/nm1233 · Cited by 320 · see citing works

Clearance of apoptotic and necrotic cells and its immunological consequences

Krysko, D. V., D’Herde, K., & Vandenabeele, P. (2006) · Apoptosis · doi:10.1007/s10495-006-9527-8 · Cited by 316 · see citing works

Microglial clearance function in health and disease

Napoli, I., & Neumann, H. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.06.046 · Cited by 312 · see citing works

The clearance of dying cells: table for two

Green, D. R., Oguin, T. H., & Martinez, J. (2016) · Cell Death & Differentiation · doi:10.1038/cdd.2015.172 · Cited by 314 · see citing works

Semaphorin 7A initiates T-cell-mediated inflammatory responses through α1β1 integrin

Suzuki, K., Okuno, T., Yamamoto, M., Pasterkamp, R. J., Takegahara, N., Takamatsu, H., Kitao, T., Takagi, J., Rennert, P. D., Kolodkin, A. L., et al. (2007) · Nature · doi:10.1038/nature05652 · Cited by 309 · see citing works

Mechanisms and Consequences of Defective Efferocytosis in Atherosclerosis

Yurdagul, A., Doran, A. C., Cai, B., Fredman, G., & Tabas, I. A. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2017.00086 · Cited by 300 · see citing works

Phagocytosis of Apoptotic Cells in Resolution of Inflammation

Kourtzelis, I., Hajishengallis, G., & Chavakis, T. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00553 · Cited by 301 · see citing works

Astrocytes and microglia play orchestrated roles and respect phagocytic territories during neuronal corpse removal in vivo

Damisah, E. C., Hill, R. A., Rai, A., Chen, F., Rothlin, C. V., Ghosh, S., & Grutzendler, J. (2020) · Science Advances · doi:10.1126/sciadv.aba3239 · Cited by 301 · see citing works

Viral apoptotic mimicry

Amara, A., & Mercer, J. (2015) · Nature Reviews Microbiology · doi:10.1038/nrmicro3469 · Cited by 294 · see citing works

The role of efferocytosis in atherosclerosis

Kojima, Y., Weissman, I. L., & Leeper, N. J. (2017) · Circulation · doi:10.1161/circulationaha.116.025684 · Cited by 289 · see citing works

Microglia in Alzheimer’s disease: pathogenesis, mechanisms, and therapeutic potentials

Miao, J., Ma, H., Yang, Y., Liao, Y., Lin, C., Zheng, J., Yu, M., & Lan, J. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1201982 · Cited by 293 · see citing works

Targeting Tumor Antigens to Secreted Membrane Vesicles In vivo Induces Efficient Antitumor Immune Responses

Zeelenberg, I. S., Ostrowski, M., Krumeich, S., Bobrie, A., Jancic, C. C., Boissonnas, A., Delcayre, A. X., Pecq, J. L., Combadière, B., Amigorena, S., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-3163 · Cited by 286 · see citing works

Evidence for Phagocytosis of Influenza Virus-Infected, Apoptotic Cells by Neutrophils and Macrophages in Mice

Hashimoto, Y., Moki, T., Takizawa, T., Shiratsuchi, A., & Nakanishi, Y. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.4.2448 · Cited by 285 · see citing works

The macrophage and the apoptotic cell: an innate immune interaction viewed simplistically?

Gregory, C. D., & Devitt, A. (2004) · Immunology · doi:10.1111/j.1365-2567.2004.01959.x · Cited by 285 · see citing works

Eating the Dead

(2002) · Science s STKE · doi:10.1126/stke.2002.132.tw172

The opsonin MFG-E8 is a ligand for the αvβ5 integrin and triggers DOCK180-dependent Rac1 activation for the phagocytosis of apoptotic cells

Akakura, S., Singh, S., Spataro, M., Akakura, R., Kim, J., Albert, M. L., & Birge, R. B. (2003) · Experimental Cell Research · doi:10.1016/j.yexcr.2003.09.011 · Cited by 229 · see citing works

Expression of Developmental Endothelial Locus-1 in a Subset of Macrophages for Engulfment of Apoptotic Cells

Hanayama, R., Tanaka, M., Miwa, K., & Nagata, S. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.6.3876 · Cited by 142 · see citing works

Masking of Phosphatidylserine Inhibits Apoptotic Cell Engulfment and Induces Autoantibody Production in Mice

Asano, K., Miwa, M., Miwa, K., Hanayama, R., Nagase, H., Nagata, S., & Tanaka, M. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040342 · Cited by 268 · see citing works

Two-Step Engulfment of Apoptotic Cells

Toda, S., Hanayama, R., & Nagata, S. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05993-11 · Cited by 124 · see citing works