The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
A gene inducible by serum growth factors encodes a member of the steroid and thyroid hormone receptor superfamily.
Open accessAbstract
We previously identified, by cDNA cloning, a set of genes that are expressed during the G0/G1 transition (cell cycle reentry) in mouse fibroblasts. These immediate early genes are transcriptionally activated within minutes of addition of serum or purified growth factors, and their mRNAs are superinduced in the presence of protein-synthesis inhibitors. We report here that one of these genes, represented by nur/77 cDNA (originally called 3CH77), encodes a member of the superfamily of ligand-binding transcription factors that includes the steroid and thyroid hormone receptors. The nur/77 cDNA sequence encodes a protein of 601 amino acids containing two regions of sequence similarity to members of this nuclear receptor superfamily, corresponding to their DNA-binding and ligand-binding domains. These results suggest that the growth factor-inducible immediate early gene nur/77 encodes a ligand-binding protein that regulates the genomic response to growth factors.
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Cites
Kozak, M. (1986) · Cell · doi:10.1016/0092-8674(86)90762-2 · Cited by 4,741
A human retinoic acid receptor which belongs to the family of nuclear receptors
Petkovich, M., Brand, N. J., Krust, A., & Chambon, P. (1987) · Nature · doi:10.1038/330444a0 · Cited by 2,214
Identification of a receptor for the morphogen retinoic acid
Giguere, V., Ong, E. S., Segui, P., & Evans, R. M. (1987) · Nature · doi:10.1038/330624a0 · Cited by 1,965
Identification of a set of genes expressed during the G0/G1 transition of cultured mouse cells.
Lau, L. F., & Nathans, D. (1985) · The EMBO Journal · doi:10.1002/j.1460-2075.1985.tb04057.x · Cited by 567
Self-citation
Cited by
Danielian, P. S., White, R., Lees, J. A., & Parker, M. G. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05141.x · Cited by 803
Differential expression of immediate early genes in the hippocampus and spinal cord
Wisden, W., Errington, M. L., Williams, S., Dunnett, S. B., Waters, C., Hitchcock, D., Evan, G., Bliss, T. V. P., & Hunt, S. P. (1990) · Neuron · doi:10.1016/0896-6273(90)90118-y · Cited by 674
Cytochrome c Release and Apoptosis Induced by Mitochondrial Targeting of Nuclear Orphan Receptor TR3
Li, H., Kolluri, S. K., Gu, J., Dawson, M. I., Cao, X., Hobbs, P. D., Lin, B., Chen, G.-Q., Lu, J.-S., Lin, F., et al. (2000) · Science · doi:10.1126/science.289.5482.1159 · Cited by 667
Evolution of the nuclear receptor gene superfamily.
Laudet, V., Hänni, C., Coll, J., Catzeflis, F., & Stéhelin, D. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05139.x · Cited by 666
Class II histone deacetylases: versatile regulators
Verdin, E., Dequiedt, F., & Kasler, H. G. (2003) · Trends in Genetics · doi:10.1016/s0168-9525(03)00073-8 · Cited by 664
Metadata
- Authors
- Hazel, T. G., Nathans, D., & Lau, L. F.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1988-11
- Volume
- 85
- Issue
- 22
- Pages
- 8444-8448
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1968199586
- Cited by
- 515
- References
- 4
- FWCI
- 10.89
- Type
- journal article
- Language
- en
- Open access
- green
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- Hazel, T. G., Nathans, D., & Lau, L. F. (1988). A gene inducible by serum growth factors encodes a member of the steroid and thyroid hormone receptor superfamily. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.85.22.8444
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