Cited by 664Histone Deacetylase Inhibitors ResearchGenomics and Chromatin DynamicsEpigenetics and DNA Methylation

Class II histone deacetylases: versatile regulators

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Verdin, Eric, Dequiedt, Franck, Kasler, Herbert G.·2003·Trends in Genetics

Abstract

Histone acetylation and deacetylation play essential roles in modifying chromatin structure and regulating gene expression in eukaryotes. Histone deacetylases (HDACs) catalyze the deacetylation of lysine residues in the histone N-terminal tails and are found in large multiprotein complexes with transcriptional co-repressors. Human HDACs are grouped into three classes based on their similarity to known yeast factors: class I HDACs are similar to the yeast transcriptional repressor yRPD3, class II HDACs to yHDA1 and class III HDACs to ySIR2. In this review, we focus on the biology of class II HDACs. These newly discovered enzymes have been implicated as global regulators of gene expression during cell differentiation and development. We discuss their emerging biological functions and the molecular mechanisms by which they are regulated.

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Crossref · 10.1016/s0168-9525(03)00073-8

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Authors
Verdin, E., Dequiedt, F., & Kasler, H. G.
Affiliations
University of California, San Francisco (US)
Venue
Trends in Genetics
Publisher
Elsevier BV
Published
2003-05
Volume
19
Issue
5
Pages
286-293
ISSN
0168-9525 (ISSN-L)
OpenAlex
W2121296685
Cited by
664
References
91
Citations by year
2026: 7 · 2025: 16 · 2024: 17 · 2023: 9 · 2022: 7 · 2021: 17 · 2020: 22 · 2019: 21 · 2018: 27 · 2017: 20 · 2016: 22 · 2015: 34 · 2014: 21 · 2013: 38 · 2012: 45
FWCI
3.14
Type
journal article
Language
en
Open access
Locations
  • Trends in Genetics (publishedVersion)
  • PubMed (publishedVersion)
  • ORBi (University of Liège) (submittedVersion, other-oa)
Funders
  • Sandler Foundation
  • Gladstone Institutes
  • National Institutes of Health
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords
class II histone deacetylases, histone deacetylation, histone acetylation, chromatin structure, gene expression regulation, corepressors, cell differentiation, development (biology), HDAC3, HDAC4, HDAC7
MeSH terms
Animals, Histone Deacetylases, Histones, Humans, Lysine

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